Research Article

Evaluation and Comparison of Three Types of Spray Dried Coprocessed Excipient Avicel® for Direct Compression

Table 2

Physical characteristics of CPE.

Measured valueAvicel CE 15Avicel DGAvicel HFE 102

Fw [g·s−1]NANA
θr [°]NANA
θs [°]
HR1.241.331.24
CI19.4624.9819.19
DB [g·mL−1]
DT [g·mL−1]
DP [g·mL−1]
[%]64.386.774.1
MPS [µm]111.8123.0145.0
 [µm]21.5522.5541.93
 [µm]99.7374.38132.16
 [µm]221.06276.8267.37
SSA [m2·g−1]0.51.20.6
[%]
UF3 [%]
UF24 [%]
pH5.527.196.99

Fw: flow through the orifice; θr: angle of repose (); θs: angle of slide; HR: Hausner ratio; CI: compressibility index; DB: bulk density; DT: tapped density; DP: pycnometric density; : porosity; MPS: mean particle size; , , and : diameters at which 10, 50, and 90% of the sample’s mass are comprised of particles with a diameter less than this value; SSA: specific surface area; : moisture content; UF3: undissolved fraction after 3 min; UF24: undissolved fraction after 24 hours; pH (2% solution); N/A: not applicable.