Optimization of the Cytotoxic Activity of Three<i> Streptomyces</i> Strains Isolated from Guaviare River Sediments (Colombia, South America)

<table class="fixed-width table-group" id="tab9"><tr><td><table class="table"><colgroup><col style="width:4.05em"/><col style="width:4.65em"/><col style="width:4.23em"/><col style="width:2.99em"/></colgroup><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td class="align_left"><b>Isolate</b></td><td class="align_center"><span style="width: 45.6ptpx;"><svg height="11.9662pt" id="M38" style="vertical-align:-5.9009pt" version="1.1" viewbox="-0.0498162 -6.0653 45.6 11.9662" width="45.6pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M560 102L544 134C516 105 480 87 475 87C467 87 468 98 475 138C496 256 522 364 546 454H533L417 428L373 236C355 209 268 82 229 82C212 82 202 98 218 181C235 267 258 364 284 449L274 454L153 433L59 30C44 -36 21 -130 21 -169C21 -227 36 -246 61 -246C94 -246 133 -219 142 -207L139 -201C120 -182 101 -133 101 -43C101 -15 105 15 113 33H115C122 9 140 -12 159 -12C189 -12 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286 6L348 45V-13C429 10 524 22 549 26V64ZM348 85C326 71 311 69 291 69C249 69 176 113 176 235C176 387 255 409 276 409C307 409 333 392 348 358V85Z" id="g22-98"></path></g><g transform="matrix(.0091,0,0,-0.0091,32.945,3.668)"><path d="M476 46L464 83C454 79 442 75 430 75C414 75 398 88 398 135V295C398 350 389 395 345 427C317 448 285 457 244 457C184 446 112 410 75 385C53 368 40 356 40 337C40 308 78 285 104 285C125 285 141 292 148 318C156 348 165 374 177 388C187 399 198 405 211 405C250 405 271 368 271 310V285C248 264 170 239 110 217C56 197 31 172 31 119C31 55 82 -12 169 -12C188 -12 236 20 275 46C280 35 287 21 302 9C315 -3 336 -12 364 -12L476 46ZM271 85C253 72 242 68 228 68C205 68 167 87 167 142C167 176 183 193 214 209C235 219 252 230 271 241V85Z" id="g22-95"></path></g><g transform="matrix(.0091,0,0,-0.0091,37.139,3.668)"><path d="M492 445H306V408C355 399 365 387 354 356C337 306 301 199 279 149L206 365C196 394 203 400 246 408V445H-7V408C42 400 55 390 73 347C90 308 146 165 199 20C204 6 205 -9 200 -25C197 -37 191 -47 181 -65C164 -93 140 -112 101 -132C81 -145 73 -154 73 -172C73 -210 117 -238 147 -238C164 -238 178 -233 185 -211C204 -155 222 -94 291 67C350 203 384 289 408 339C433 390 443 400 492 408V445Z" id="g22-119"></path></g><g transform="matrix(.0091,0,0,-0.0091,41.617,3.668)"><path d="M283 271C283 451 220 610 70 710L48 683C146 603 207 443 207 271S149 -59 48 -142L70 -169C220 -67 283 90 283 271Z" id="g50-42"></path></g></svg></span></td><td class="align_center"><span style="width: 7.39389ptpx;"><svg height="9.49471pt" id="M39" style="vertical-align:-0.1933298pt" version="1.1" viewbox="-0.0498162 -9.30138 7.39389 9.49471" width="7.39389pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M538 105L516 132C487 96 462 81 452 81S434 90 431 112C411 257 402 362 394 460C381 623 361 703 273 703C231 703 185 680 158 657L164 628C177 634 192 636 200 636C230 636 251 616 263 547C270 506 273 480 276 429C205 269 104 116 21 9L30 -12C67 -6 92 5 120 12C168 102 237 237 285 346L307 104C314 31 329 -12 370 -12C415 -12 479 18 538 105Z" id="g5-233"></path></g></svg><b> (day)</b></span></td><td class="align_center"><span style="width: 13.8409ptpx;"><svg height="11.6699pt" id="M40" style="vertical-align:-0.1149998pt" version="1.1" viewbox="-0.0498162 -11.5549 13.8409 11.6699" width="13.8409pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M660 23C638 31 621 43 599 66C580 87 558 119 523 175C493 221 456 287 441 317C508 344 566 392 566 480C566 542 539 586 499 613C458 640 408 650 320 650H39V615C112 608 121 598 121 518V134C121 51 110 42 35 35V0H337V35C261 42 252 51 252 134V280H271C303 280 321 267 337 237C366 184 393 130 419 89C460 26 498 -2 624 -8C637 -8 648 -9 654 -9L660 23ZM252 320V563C252 584 254 594 261 600C267 606 281 610 306 610C362 610 424 572 424 465C424 414 410 374 376 346C354 327 320 320 278 320H252Z" id="g13-80"></path></g><g transform="matrix(.0091,0,0,-0.0091,8.58,-5.741)"><path d="M440 180C404 113 397 110 338 110H183L298 220C398 316 438 379 438 456C438 568 354 635 254 635C192 635 138 610 101 572L36 479L69 452C103 500 144 541 204 541C270 541 306 494 306 425C306 350 267 276 197 193C148 136 89 81 36 30V0H440C451 42 463 106 480 167L440 180Z" id="g22-48"></path></g></svg></span></td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td class="align_left"><b>73</b></td><td class="align_center">1.18</td><td class="align_center">1.71</td><td class="align_center">0.99</td></tr><tr><td class="align_left" colspan="4"><hr/></td></tr><tr><td class="align_left"><b>386</b></td><td class="align_center">0.98</td><td class="align_center">2.64</td><td class="align_center">0.95</td></tr><tr><td class="align_left" colspan="4"><hr/></td></tr><tr><td class="align_left"><b>519</b></td><td class="align_center">0.50</td><td class="align_center">1.26</td><td class="align_center">0.98</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Results of Gompertz model growth rate (<svg height="9.39034pt" id="M36" style="vertical-align:-3.42943pt" version="1.1" viewbox="-0.0498162 -5.96091 7.34167 9.39034" width="7.34167pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M538 96L524 119C492 88 454 63 446 63C439 63 434 70 440 101C463 223 491 341 518 448H508L433 422L401 276C355 192 240 56 188 56C163 56 154 89 163 133C184 233 207 338 235 443L230 448L152 424L58 17C40 -60 23 -143 23 -185C23 -241 42 -261 63 -261C92 -261 117 -241 125 -227L124 -221C109 -209 89 -165 89 -103C89 -55 96 -13 105 26H107C121 -3 134 -12 151 -12C172 -12 194 -5 221 16C279 61 330 124 384 194H386C381 159 377 141 368 105C343 3 363 -12 383 -12C416 -12 486 35 538 96Z" id="g113-234"></path></g></svg>Max), the lag time <span class="nowrap"><svg height="11.5564pt" id="M37" style="vertical-align:-2.26807pt" version="1.1" viewbox="-0.0498162 -9.28833 16.3323 11.5564" width="16.3323pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M300 -147C201 -63 143 98 143 270S200 602 300 686L282 710C136 610 70 450 70 271V270C70 89 136 -72 282 -170L300 -147Z" id="g113-41"></path></g><g transform="matrix(.013,0,0,-0.013,4.498,0)"><path d="M529 97L508 118C475 75 449 58 438 58C428 58 421 66 415 104C393 234 374 403 364 496C345 670 307 712 254 712C220 712 174 691 153 669L161 645C176 653 194 658 206 658C237 658 261 640 278 562C287 522 290 483 293 434C223 269 110 105 23 9L32 -12C59 -6 85 0 108 7C152 64 251 252 300 366C307 297 315 221 337 82C346 24 363 -12 393 -12C425 -12 475 13 529 97Z" id="g113-233"></path></g><g transform="matrix(.013,0,0,-0.013,11.672,0)"><path d="M275 270C275 450 212 609 64 710L45 686C145 604 203 442 203 270S147 -63 45 -147L64 -170C213 -68 275 89 275 270Z" id="g113-42"></path></g></svg>,</span> and the coefficients of correlation (R<sup>2</sup>).</div>

BioMed Research International

tab9

Table 9

Table 9: Optimization of the Cytotoxic Activity of Three<i> Streptomyces</i> Strains Isolated from Guaviare River Sediments (Colombia, South America) 

BioMed Research International

Optimization of the Cytotoxic Activity of Three Streptomyces Strains Isolated from Guaviare River Sediments (Colombia, South America)

Table 9