Research Article

Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits

Figure 1

Surgical Procedure. (a) 10 cm craniocaudal incision was made and a mucoperiosteal flap was elevated (b, c). Four identical circular defects (8 mm in diameter, two in the frontal and two in the parietal bone) were created in the calvarium using a trephine bur (d). The defects were filled with ANGIPARS, ANGIPARS plus Bio-Oss, and Bio-Oss alone and the other one is left empty (e, f). The periosteum and the calvarial skin were then sutured with 4.0 vicryl (Ethicon, Somerville, NJ, USA) and 3.0 nylon (Ethicon, Somerville, NJ, USA) sutures, respectively.
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