Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide

Figure 1

Representative tracings of spontaneous contractions of intact rat bladder strips before (Phase 1) and during (Phase 2) treatment with vehicle (0.1% DMSO) or test agent [nisoldipine (100 nM), SKF96365 (10 μM), ryanodine (10 μM), iberiotoxin (100 nM), NS1619 (30 μM), apamin (100 nM), NS309 (10 μM), Y27632 (10 μM), BIS-1 (2 μM), and Y27632 + NS309 (each 10 μM)] and then incubated with 0.003 g% H₂O₂ (Phase 3).