Table 1: Effects of specific activators and blockers on spontaneous contractions in intact bladder strips (Phase 2 values as percentages of Phase 1 values).

Drugs
(concentration)
Basal tension (%)Amplitude (%)Frequency (%)

Control (vehicle + H2O2)1386.4 ± 2.3667.5 ± 5.09103.4 ± 3.29
Nisoldipine (100 nM)679.5 ± 4.8667.8 ± 7.73103.3 ± 3.41
SKF96365 (10 µM)6100.7 ± 7.31
Ryanodine (10 µM)589.8 ± 8.2082.4 ± 8.89
Iberiotoxin (100 nM)8106.8 ± 4.43
NS1619 (30 µM)5109.2 ± 5.97
Apamin (100 nM)984.7 ± 5.64
NS309 (10 µM)680.1 ± 2.20
BIS1 (2 µM)781.0 ± 2.4568.78 ± 4.97118.4 ± 16.58
Y27632 (10 µM)9
Y27632 (10 µM) + NS309 (10 µM)5

Values are expressed as mean plus or minus SEM of 5 to 13 individual strips; significantly different from corresponding value in vehicle treated group ().