BioMed Research International / 2018 / Article / Tab 2

Research Article

Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide

Table 2

Effects of specific activators and blockers on H2O2-induced augmentation of spontaneous contractions in intact bladder strips (Phase 3 values as percentages of Phase 1 values).

DrugsBasal tension (%)Amplitude (%)Frequency (%)

Control (vehicle + H2O2)13204.6 ± 10.79216.4 ± 22.75100.7 ± 3.00
Nisoldipine + H2O26195.0 ± 14.81236.9 ± 47.62105.8 ± 5.25
SKF96365 + H2O26174.2 ± 8.85246.4 ± 56.27101.5 ± 4.95
Ryanodine + H2O25209.0 ± 20.37253.8 ± 52.82130.4 ± 13.43
Iberiotoxin + H2O28238.8 ± 13.63339.3 ± 57.8296.6 ± 8.39
NS1619 + H2O25248.3 ± 16.42318.1 ± 55.9798.8 ± 7.57
Apamin + H2O29222.5 ± 13.4884.2 ± 7.39
NS309 + H2O26208.5 ± 25.43
BIS1 + H2O27211.0 ± 22.01230.0 ± 31.13104.9 ± 9.13
Y27632 + H2O29195.4 ± 35.64
Y27632 + NS309 + H2O25

Values are expressed as mean plus or minus SEM of 5 to 13 individual strips; significantly different from corresponding value in vehicle treated group ().

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