Regulation of Spontaneous Contractions in Intact Rat Bladder Strips and the Effects of Hydrogen Peroxide
Table 2
Effects of specific activators and blockers on H2O2-induced augmentation of spontaneous contractions in intact bladder strips (Phase 3 values as percentages of Phase 1 values).
Drugs
Basal tension (%)
Amplitude (%)
Frequency (%)
Control (vehicle + H2O2)
13
204.6 ± 10.79
216.4 ± 22.75
100.7 ± 3.00
Nisoldipine + H2O2
6
195.0 ± 14.81
236.9 ± 47.62
105.8 ± 5.25
SKF96365 + H2O2
6
174.2 ± 8.85
246.4 ± 56.27
101.5 ± 4.95
Ryanodine + H2O2
5
209.0 ± 20.37
253.8 ± 52.82
130.4 ± 13.43
Iberiotoxin + H2O2
8
238.8 ± 13.63
339.3 ± 57.82
96.6 ± 8.39
NS1619 + H2O2
5
248.3 ± 16.42
318.1 ± 55.97
98.8 ± 7.57
Apamin + H2O2
9
222.5 ± 13.48
84.2 ± 7.39
NS309 + H2O2
6
208.5 ± 25.43
BIS1 + H2O2
7
211.0 ± 22.01
230.0 ± 31.13
104.9 ± 9.13
Y27632 + H2O2
9
195.4 ± 35.64
Y27632 + NS309 + H2O2
5
Values are expressed as mean plus or minus SEM of 5 to 13 individual strips; significantly different from corresponding value in vehicle treated group ().
