Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice

Figure 1

RGCs in TRPM1 KO but not in mGluR6 KO retinas showed obvious oscillations during MEA recordings. Light-evoked responses were recorded from the wild type (WT), mGluR6 KO, and TRPM1 KO RCGs. (a) Example traces of firing during a 2-s light stimulus (light/dark bar at the top of each panel). Data were obtained from the WT (upper panel), mGluR6 KO (middle panel), and TRPM1 KO (lower panel) retinas. Traces show the responses of one or more RGCs recorded on a single electrode. (b) Raster plots of spikes sorted from the firing in (a) and their resulting peristimulus time histograms (PSTHs; 5-ms bin width). In these examples, spikes were sorted into three (sustained ON, delayed ON, and transient OFF) RGCs in WT (upper), two (delayed ON and sustained OFF) RGCs in mGluR6 KO (middle), and one (sustained OFF) RGC in TRPM1 KO (lower). (c) Power spectra of firing calculated from the OFF RGCs shown in (b) (upper, WT; middle, mGluR6 KO; and lower, TRPM1 KO). A peak (~8 Hz) was detected only in TRPM1 KO.