Genetic Polymorphisms of IL1B, IL6, and TNFα in a Chinese Han Population with Pulmonary Tuberculosis

Table 3

Distributions of cytokine genotypes in the three groups.

Gene: SNPs	PTB; (%)	LTBI; (%)	HCS; (%)	PTB versus LTBI; value	OR (95%	LTBI versus HCS; value	OR (95%
IL1B
rs1143623 C>G
Genotypes
CC	75 (35.9)	63 (31.5)	74 (36.3)	Reference
GC	104 (49.8)	100 (50.0)	96 (47.1)	0.732	0.92 (0.59–1.46)	0.424	1.20 (0.77–1.86)
GG	30 (14.4)	37 (18.5)	34 (16.7)	0.239	0.69 (0.37–1.28)	0.436	1.26 (0.71–2.45)
Alleles
C	254 (60.8)	226 (56.5)	244 (59.8)	Reference
G	164 (39.2)	174 (43.5)	164 (40.2)	0.277	0.85 (0.63–1.14)	0.378	1.14 (0.90–1.50)
rs1143634 G>A
Genotypes
GG	205 (98.1)	198 (99.0)	194 (95.0)	Reference
GA	4 (1.9)	2 (1.0)	10 (5.0)	0.398	2.18 (0.36–13.3)	0.02	0.18 (0.08–0.83)
AA	0 (0)	0 (0)	0 (0)	-		-	-
Alleles
G	414 (99.0)	398 (99.0)	398 (98.0)	Reference
A	4 (1.0)	2 (1.0)	10 (2.0)	0.400	-	0.02	0.18 (0.039–0.84)
rs16944 G>A
Genotypes
GG	61 (29.2)	43 (21.5)	47 (23.0)	Reference
GA	110 (52.6)	109 (54.5)	115 (56.4)	0.321	0.78 (0.47–1.27)	0.981	0.99 (0.61–1.63)
AA	38 (18.2)	48 (24.0)	42 (20.6)	0.108	0.61 (0.33–1.12)	0.619	1.17 (0.64–2.14)
Alleles
G	232 (55.5)	195 (48.8)	209 (51.2)	Reference
A	186 (44.5)	205 (51.3)	199 (48.8)	0.108	0.79 (0.59–1.05)	0.569	1.08 (0.82–1.43)
IL6
rs2069837 A>G
Genotypes
AA	144 (68.9)	129 (64.5)	125 (61.3)	Reference
GA	56 (26.8)	68 (34.0)	70 (34.3)	0.04	0.62 (0.40–0.98)	0.812	0.95 (0.63–1.44)
GG	9 (4.3)	3 (1.5)	9 (4.4)	0.303	2.11 (0.51–8.78)	0.085	0.31 (0.08–1.18)
Alleles
A	344 (82.3)	326 (81.5)	320 (78.4)	Reference
G	74 (17.7)	74 (18.5)	88 (21.6)	0.302	0.82 (0.56–1.20)	0.611	0.92 (0.66–1.28)
rs17147230 A>T
Genotypes
AA	64 (30.6)	56 (28.0)	49 (23.9)	Reference
AT	103 (49.3)	103 (51.5)	110 (53.7)	0.580	0.87 (0.54–1.41)	0.438	0.83 (0.52–1.33)
TT	42 (20.1)	41 (20.5)	46 (22.4)	0.448	0.79 (0.43–1.45)	0.435	0.80 (0.45–1.42)
Alleles
A	231 (55.3)	215 (53.8)	208 (50.7)	Reference
T	187 (44.7)	185 (46.2)	202 (49.3)	0.494	0.9 (0.68–1.21)	0.666	0.94 (0.72–1.23)
TNFα
rs1799724 C>T
Genotypes
CC	163 (78.0)	138 (69.0)	146 (71.6)	Reference
CT	45 (21.5)	58 (29.0)	55 (27.0)	0.061	0.64 (0.40–1.02)	0.688	1.09 (0.71–1.7)
TT	1 (0.5)	4 (2.0)	3 (1.5)	0.282	0.30 (0.03–0.27)	0.603	1.04 (0.90–1.20)
Alleles
C	371 (88.8)	334 (83.5)	347 (85.0)	Reference
T	47 (11.2)	66 (16.5)	61 (15.0)		0.64 (0.42–0.98)	0.588	1.11 (0.76–1.63)
rs1799964 T>C
Genotypes
TT	127 (60.4)	137 (68.5)	142 (69.6)	Reference
CT	71 (33.8)	56 (28.0)	58 (28.4)	0.176	1.36 (0.87–2.13)	0.863	1.04 (0.67–1.61)
CC	12 (5.7)	7 (3.5)	4 (2.0)	0.404	1.55 (0.56–4.31)	0.398	1.72 (0.49–6.07)
Alleles
T	325 (77.3)	330 (84.4)	342 (83.8)	Reference
C	95 (22.6)	70 (15.6)	66 (16.2)	0.134	1.32 (0.92–1.9)	0.543	1.12 (0.77–1.63)
rs1800629 G>A
Genotypes
GG	180 (85.7)	177 (88.5)	174 (85.3)	Reference
GA	29 (13.8)	22 (11.0)	29 (14.2)	0.412	1.30 (0.70–2.40)	0.372	0.76 (0.42–1.38)
AA	1 (0.5)	1 (0.5)	1 (0.5)	-	-	0.904	0.84 (0.05–14.36)
Alleles
G	389 (92.6)	376 (94.0)	377 (89.9)	Reference
A	31 (7.4)	24 (6.0)	31 (10.1)	0.504	1.22 (0.68–2.19)	0.383	0.78 (0.45–1.36)
rs1800630 C>A
Genotypes
CC	135 (64.6)	145 (72.5)	151 (74.0)	Reference
CA	65 (31.1)	50 (25.0)	49 (24.0)	0.132	1.42 (0.89–2.25)	0.693	1.10 (0.69–1.74)
AA	9 (4.3)	5 (2.5)	4 (2.0)	0.543	1.43 (0.45–4.56)	0.728	1.27 (0.33–4.84)
Alleles
C	335 (80.1)	340 (85.0)	351 (86.0)	Reference
A	83 (19.9)	60 (15.0)	57 (14.0)	0.130	1.34 (0.92–1.97)	0.608	1.12 (0.75–1.65)
rs361525 G>A
Genotypes
GG	196 (93.3)	189 (94.5)	194 (95.1)	Reference
GA	14 (0.7)	11 (5.5)	9 (4.4)	0.911	1.05 (0.44–2.54)	0.592	1.28 (0.52–3.19)
AA	0 (0)	0 (0)	1 (0.5)	-	-	-	-
Alleles
G	406 (96.7)	389 (97.3)	397 (97.3)	Reference
A	14 (3.3)	11 (2.7)	11 (2.7)	0.912	1.05 (0.44–2.5)	0.935	1.04 (0.44–2.43)

SNPs, single nucleotide polymorphisms; CI, confidence interval; OR, odds ratio; PTB, pulmonary tuberculosis; LTBI, latent tuberculosis infection; HCS, healthy controls; adjusted by age, sex status; .