Burkholderia pseudomallei Adaptation for Survival in Stressful Conditions

Table 1

Stress-regulated genes for Burkholderia pseudomallei adaptation.

Type of stress	Stress regulated genes
	Membrane structure	Metabolism	Virulence
Salinity
High level	gene encoding Acyl-CoA dehydrogenase [27]; and cyaB [27]	gene encoding SDO [31]	bsa-encoded genes (bipD and bopE) [27], rpoE [27], mucB [27], groEL [32], and htpG [32]
Low level	-	-	-
Oxidative condition
High level	rpoE [29] and speG [29]	rpoS [34], scoA [34], cysM [34], panB [34], pdxJ [34], gene encoding SCOT [34], and genes encoding KatG and KatE [33]	dpsA [35]
Low level	-	-	-
Iron
High level	-	fur [36]	mba [37], pch [37], and bhu/hmu [17]
Low level	-	BPSS0495 [17]	fur [36], bfmR [38], and genes encoding T6SS [76]
Oxygen
High level	-	-	-
Low level	-	Genes encoding ATP synthases (atpA and atpD), arginine and pyruvate fermentation (aceE, arcD and tatA), electron transport proteins (aarC,cydA, cydB, mocA, and BPSL1260), and polyhydroxybutyrate synthase (bdhA-2) [25]	Genes encoding flagella-mediated motility (flgA, flgC, flgK,flgM, fliF, fliJ, fliK, and pilT), stress-related proteins (clpB, rpoH, and rpoS), and virulence factors (bopE, bipC, bipD, orgA,and pilA) [25]