Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases

Table 3

Effects and mechanisms of IL-37 in infectious diseases.

Diseases	Model	Effect	Mechanism	Reference
Endotoxic shock	hIL-37tg mice	Attenuates shock state	↓IL-6 ↓IL-1β ↓IL-17; ↓IFN-γ ↓DCs	[3]
Aspergillus infection	Mice	Attenuates neutrophil infiltration, lung injury, and cystic fibrosis	↓NLRP3 inflammasome	[16]
Diffuse candidiasis	hIL-37tg mice	Increases mortality rate	↓TNF-α; ↓Neutrophils recruitment	[42]

DCs: dendritic cells. ↓: downregulate.