A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3

<div><i>The possible mechanism of attenuation of vildagliptin on endothelial dysfunction</i>. Vildagliptin attenuates endothelial dysfunction in diabetic rats through activating<i> Pon1</i> expression in aorta to inhibit oxLDL production; inhibiting Bhmt expression to reduce Met and SAM production; inhibiting<i> Angptl3</i> expression to activate LPL activity and thereby reduce plasma TG level. LDL: low-density lipoprotein; Pon1: paraoxonase 1; oxLDL: oxidized low-density lipoprotein; Hcy: homocysteine; Bhmt: betaine-homocysteine S-methyltransferase; Met: methionine, SAM: S-adenosylmethionine; TG: triglyceride.</div>

BioMed Research International

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Figure 5

Figure 5: A Possible Mechanism: Vildagliptin Prevents Aortic Dysfunction through Paraoxonase and Angiopoietin-Like 3 