Research Article

AEG-1 Contributes to Metastasis in Hypoxia-Related Ovarian Cancer by Modulating the HIF-1alpha/NF-kappaB/VEGF Pathway

Table 2

Associations of HIF-1α and AEG-1 levels with clinicopathologic features of EOC patients.

VariableCases (N)AEG-1 high levelsHIF-1α high levels
n (%)pn (%)p

Age0.2710.697
 ≤556343 (68.3)39 (61.9)
 >5510764 (59.8)63 (58.9)
Metastasis0.0050.001
 Negative2811 (39.3)9 (32.1)
 Positive14296 (67.6)93 (65.5)
Histological type0.0020.006
 Serous11179 (71.2)75 (67.6)
 Others5928 (47.5)27 (45.8)
Grade0.6440.035
 G1-210165 (64.4)54 (53.5)
 G36942 (60.9)48 (69.6)
FIGO stage0.0000.001
 I-II4519 (42.2)18 (40.0)
 III-IV12588 (70.4)84 (67.2)
Residual tumor (cm)0.0000.000
 ≤18137 (45.7)34 (42.0)
 >18970 (78.7)68 (76.4)
Ascites (ml)0.0080.019
 ≤5006231 (50.0)30 (48.4)
 >50010876 (70.4)72 (66.7)
Menopausal status0.2510.094
 No5538 (69.1)38 (69.1)
 Yes11569 (60.0)64 (55.7)
Preoperative CA125 level (U/ml)0.9130.820
 ≤35149 (64.3)8 (57.1)
 >3515698 (62.8)94 (60.3)
Chemo.0.2610.648
 No6135 (57.4)38 (62.3)
 Yes10972 (66.1)64 (58.7)