Research Article
AEG-1 Contributes to Metastasis in Hypoxia-Related Ovarian Cancer by Modulating the HIF-1alpha/NF-kappaB/VEGF Pathway
Table 2
Associations of HIF-1α and AEG-1 levels with clinicopathologic features of EOC patients.
| Variable | Cases (N) | AEG-1 high levels | HIF-1α high levels | n (%) | p | n (%) | p |
| Age | | | 0.271 | | 0.697 | ≤55 | 63 | 43 (68.3) | | 39 (61.9) | | >55 | 107 | 64 (59.8) | | 63 (58.9) | | Metastasis | | | 0.005 | | 0.001 | Negative | 28 | 11 (39.3) | | 9 (32.1) | | Positive | 142 | 96 (67.6) | | 93 (65.5) | | Histological type | | | 0.002 | | 0.006 | Serous | 111 | 79 (71.2) | | 75 (67.6) | | Others | 59 | 28 (47.5) | | 27 (45.8) | | Grade | | | 0.644 | | 0.035 | G1-2 | 101 | 65 (64.4) | | 54 (53.5) | | G3 | 69 | 42 (60.9) | | 48 (69.6) | | FIGO stage | | | 0.000 | | 0.001 | I-II | 45 | 19 (42.2) | | 18 (40.0) | | III-IV | 125 | 88 (70.4) | | 84 (67.2) | | Residual tumor (cm) | | | 0.000 | | 0.000 | ≤1 | 81 | 37 (45.7) | | 34 (42.0) | | >1 | 89 | 70 (78.7) | | 68 (76.4) | | Ascites (ml) | | | 0.008 | | 0.019 | ≤500 | 62 | 31 (50.0) | | 30 (48.4) | | >500 | 108 | 76 (70.4) | | 72 (66.7) | | Menopausal status | | | 0.251 | | 0.094 | No | 55 | 38 (69.1) | | 38 (69.1) | | Yes | 115 | 69 (60.0) | | 64 (55.7) | | Preoperative CA125 level (U/ml) | | | 0.913 | | 0.820 | ≤35 | 14 | 9 (64.3) | | 8 (57.1) | | >35 | 156 | 98 (62.8) | | 94 (60.3) | | Chemo. | | | 0.261 | | 0.648 | No | 61 | 35 (57.4) | | 38 (62.3) | | Yes | 109 | 72 (66.1) | | 64 (58.7) | |
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