Suppression of IL-6 Gene by shRNA Augments Gemcitabine Chemosensitization in Pancreatic Adenocarcinoma Cells

Figure 6

Antitumor activity of shIL-6 and gemcitabine in the xenograft model. Nude mice were randomly assigned to the following four groups: PANC-1 cells with stably expressing control vector, control vector with 100 mg/kg gemcitabine daily for 10 d via i.p. injection, shIL-6 alone, and shIL-6 plus 10 mg/kg gemcitabine daily for 10 d via i.p. injection. (a) Macrograph of the tumor tissues obtained on week 5. (b) Comparison of the tumor volumes as function of time.

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