Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2018, Article ID 3274641, 7 pages
https://doi.org/10.1155/2018/3274641
Research Article

miR-142-5p in Bone Marrow-Derived Mesenchymal Stem Cells Promotes Osteoporosis Involving Targeting Adhesion Molecule VCAM-1 and Inhibiting Cell Migration

1Department of Orthopedic Surgery, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan 653100, China
2Huai’an Second People’s Hospital, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, Jiangsu 223200, China
3Health Screening Center, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, 21 Nieer Road, Yuxi, Yunnan 653100, China
4Department of Orthopedics, The First People’s Hospital of Kunming, Kunming, Yunnan 650011, China
5Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150006, China
6Department of Orthopedics, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, China
7Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA 5001, Australia

Correspondence should be addressed to Xiguang Zhang; moc.361@gxzkwg and Cory J. Xian; ua.ude.asinu@naix.yroc

Received 2 November 2017; Revised 27 January 2018; Accepted 28 February 2018; Published 29 March 2018

Academic Editor: Weijie Fu

Copyright © 2018 Zhaowei Teng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. A. Kanis, E. V. McCloskey, H. Johansson, C. Cooper, R. Rizzoli, and J.-Y. Reginster, “European guidance for the diagnosis and management of osteoporosis in postmenopausal women,” Osteoporosis International, vol. 24, no. 1, pp. 23–57, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Roux and K. Briot, “Imminent fracture risk,” Osteoporosis International, vol. 28, no. 6, pp. 1765–1769, 2017. View at Publisher · View at Google Scholar · View at Scopus
  3. J. P. Bidwell, M. B. Alvarez, M. Hood Jr., and P. Childress, “Functional impairment of bone formation in the pathogenesis of osteoporosis: The bone marrow regenerative competence,” Current Osteoporosis Reports, vol. 11, no. 2, pp. 117–125, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Epstein, “Update of current therapeutic options for the treatment of postmenopausal osteoporosis,” Clinical Therapeutics, vol. 28, no. 2, pp. 151–173, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Heiss, P. Govindarajan, G. Schlewitz et al., “Induction of osteoporosis with its influence on osteoporotic determinants and their interrelationships in rats by DEXA,” Medical Science Monitor, vol. 18, no. 6, pp. BR199–BR207, 2012. View at Google Scholar · View at Scopus
  6. V. Schramke and R. Allshire, “Erratum: Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing,” Science, vol. 301, pp. 1069–1074, 2003. View at Google Scholar · View at Scopus
  7. K.-I. Noma, T. Sugiyama, H. Cam et al., “RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing,” Nature Genetics, vol. 36, no. 11, pp. 1174–1180, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Zhang, X. Wei, and L. Xu, “MiR-150 promotes the proliferation of lung cancer cells by targeting P53,” FEBS Letters, vol. 587, no. 15, pp. 2346–2351, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Yin, P.-Q. Wang, W.-P. Xu et al., “Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region,” Hepatology, vol. 58, no. 6, pp. 1964–1976, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Yang, D. Wu, J. Zhu et al., “Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1,” Oncology Reports, vol. 30, no. 2, pp. 877–889, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. D. N. Kalu, “The ovariectomized rat model of postmenopausal bone loss,” Bone and Mineral, vol. 15, no. 3, pp. 175–191, 1991. View at Publisher · View at Google Scholar · View at Scopus
  12. J. R. Hartke, “Preclinical development of agents for the treatment of osteoporosis,” Toxicologic Pathology, vol. 27, no. 1, pp. 143–147, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Lamouille, D. Subramanyam, R. Blelloch, and R. Derynck, “Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by micrornas,” Current Opinion in Cell Biology, vol. 25, no. 2, pp. 200–207, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. J. B. Lian, G. S. Stein, A. J. van Wijnen et al., “MicroRNA control of bone formation and homeostasis,” Nature Reviews Endocrinology, vol. 8, no. 4, pp. 212–227, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Song and Y.-K. Kim, “Identification of the role of miR-142-5p in alzheimer’s disease by comparative bioinformatics and cellular analysis,” Frontiers in Molecular Neuroscience, vol. 10, article no. 227, 2017. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Sharma, “Immunomodulation: A definitive role of microRNA-142,” Developmental & Comparative Immunology, vol. 77, pp. 150–156, 2017. View at Publisher · View at Google Scholar · View at Scopus
  17. X. Bai, Y. Zhou, and M. Yang, “MicroRNA-142-5p induces cancer stem cell-like properties of cutaneous squamous cell carcinoma via inhibiting PTEN,” Journal of Cellular Biochemistry, 2017. View at Google Scholar
  18. S. Pathak, W.-J. Meng, S. K. Nandy et al., “Radiation and SN38 treatments modulate the expression of microRNAs, cytokines and chemokines in colon cancer cells in a p53-directed manner,” Oncotarget , vol. 6, no. 42, pp. 44758–44780, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. H. E. Olivey and E. C. Svensson, “Epicardial-myocardial signaling directing coronary vasculogenesis,” Circulation Research, vol. 106, no. 5, pp. 818–832, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Schlesinger and G. Bendas, “Vascular cell adhesion molecule-1 (VCAM-1) - An increasing insight into its role in tumorigenicity and metastasis,” International Journal of Cancer, vol. 136, no. 11, pp. 2504–2514, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. U. El-Shinnawi and M. Soory, “Actions of adjunctive nutritional antioxidants in periodontitis and prevalent systemic inflammatory diseases,” Endocrine, Metabolic & Immune Disorders—Drug Targets, vol. 15, no. 4, pp. 261–276, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. G. Wang, J. Wang, D. Sun et al., “Short-term hypoxia accelerates bone loss in ovariectomized rats by suppressing osteoblastogenesis but enhancing osteoclastogenesis,” Medical Science Monitor, vol. 22, pp. 2961–2971, 2016. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Sun, X. Zheng, Y. Chen et al., “Enhancement of osteogenesis post-splenectomy does not attenuate bone loss in ovariectomized rats,” Journal of Orthopaedic Research, vol. 33, no. 9, pp. 1356–1363, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. F. H. Zhou, B. K. Foster, X.-F. Zhou, A. J. Cowin, and C. J. Xian, “TNF-α mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats,” Journal of Bone and Mineral Research, vol. 21, no. 7, pp. 1075–1088, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. P. P. Dwivedi, R. H. Grose, J. Filmus et al., “Regulation of bone morphogenetic protein signalling and cranial osteogenesis by Gpc1 and Gpc3,” Bone, vol. 55, no. 2, pp. 367–376, 2013. View at Publisher · View at Google Scholar · View at Scopus