Saccharomyces cerevisiae-Derived Mannan Does Not Alter Immune Responses to Aspergillus Allergens

Figure 3

Goblet cells (GCs) were induced by MN treatment in allergic mice. While GCs were not found in the airways of naïve animals (a), GCs were abundant in allergic animals (b). MN-treated allergic mice also had GCs liberally interspersed within the airway lining (c). Enumeration of GCs per 30 epithelial cells in 10 high power fields (HPF) showed that MN treatment led to an increase in the number of GCs in allergic mice (d). This treatment also resulted in increased expression of Muc5ac (e) and Muc5b (f) in allergic mice. Data are represented as the mean and standard error in –10 mice per group. Data in each group were analyzed by one-way ANOVA with Dunn’s multiple comparisons test, and denotes , denotes , and denotes .

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