TY - JOUR A2 - Zhai, Lidong AU - Liu, Shaojuan AU - He, Liuqin AU - Yao, Kang PY - 2018 DA - 2018/03/21 TI - The Antioxidative Function of Alpha-Ketoglutarate and Its Applications SP - 3408467 VL - 2018 AB - Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the oxidation of nutrients (i.e., amino acids, glucose, fatty acids) and then provides energy for cell processes. As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogen peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation. Recent studies also show that AKG has alleviative effect on oxidative stress as a source of energy and an antioxidant in mammalian cells. In this review, we highlight recent advances in the antioxidative function of AKG and its applications in animals and humans. SN - 2314-6133 UR - https://doi.org/10.1155/2018/3408467 DO - 10.1155/2018/3408467 JF - BioMed Research International PB - Hindawi KW - ER -