High Mobility Group Box Protein 1 Serves as a Potential Prognostic Marker of Lung Cancer and Promotes Its Invasion and Metastasis by Matrix Metalloproteinase-2 in a Nuclear Factor-κB-Dependent Manner

Table 2

The relationship between high mobility group box protein 1 staining and the clinicopathological characteristics of 90 lung cancer patients.

Variables	HMGB-1 staining
	Low (%)	High (%)	Total
Age
≥60 years	23 (41.8)	32 (58.2)	55	0.828
<60 years	16 (45.7)	19 (54.3)	35
Gender
Male	19 (38.8)	30 (61.2)	49	0.396
Female	20 (48.8)	21 (51.2)	41
Tumor size
≥4 cm	23 (44.2)	28 (55.8)	51	0.832
<4 cm	16 (41.0)	23 (59.0)	39
pT status
pT1-pT2	34 (50.7)	33 (49.3)	67	0.027
pT3-pT4	5 (21.7)	18 (78.3)	23
pN status
pN0	22(56.4)	17(43.6)	39	0.019
pN1–pN3	10(27.8)	26(72.2)	36
TNM stage
I-II	35 (50.7)	34 (49.3)	69	0.012
III	4 (19.0)	17 (81.0)	21

The Student -test for value.