Immunoglobulin E and G Levels in Predicting Minimal Change Disease before Renal Biopsy
Table 1
Baseline characteristics of patients with or without minimal change disease (MCD).
Characteristics
All (n = 142)
MCD (n = 38)
non-MCD (n = 104)
p value
Age (years)
42.4 ± 17.0
29.9 ± 13.3
46.8 ± 15.9
<0.001
Men [n (%)]
82 (57.7%)
28 (73.7%)
54 (51.9%)
0.022
WBC (x103/mm3)
7.9 ± 3.0
7.6 ± 2.6
8.0 ± 3.2
0.562
Hemoglobin (g/dl)
12.9 ± 2.4
14.7 ± 2.2
12.2 ± 2.1
<0.001
Platelet count (x103/mm3)
264 ± 75
276 ± 65
260 ± 78
0.258
Blood urea nitrogen (mg/dl)
19.6 ± 11.7
20.8 ± 15.3
19.2 ± 10.1
0.486
Creatinine (mg/dl)
0.93 ± 0.40
0.88 ± 0.36
0.95 ± 0.42
0.313
Total protein (g/dl)
5.1 ± 1.1
4.8 ± 1.3
5.2 ± 1.0
0.108
Serum sodium (meq/L)
140.2 ± 3.5
139.2 ± 3.8
140.5 ± 3.4
0.071
Serum Potassium (meq/L)
4.0 ± 0.5
4.1 ± 0.5
3.9 ± 0.5
0.109
Proteinuria (g/day)
8.7 ± 7.3
13.2 ± 8.5
7.0 ± 5.9
<0.001
24 hours urine output (ml)
1951 ± 972
1950 ± 1130
1951 ± 915
0.998
Microscopic hematuria [n (%)]
3 (2.1%)
0 (0.0%)
3 (2.9%)
0.564
Serology markers
Immunoglobulin G (mg/dl)
681.2 ± 381.5
500.7 ± 411.1
757.7 ± 347.2
0.001
Immunoglobulin M (mg/dl)
123.7 ± 68.8
127.0 ± 48.6
122.4 ± 75.2
0.751
Immunoglobulin A (mg/dl)
287.6 ± 113.8
269.1 ± 102.4
294.7 ± 117.6
0.253
Immunoglobulin E (mg/dl)
187 (47-639)
597 (146-1940)
108 (29-367)
<0.001
Data are presented as mean ± SD, n (%), or median (interquartile range) unless otherwise specified. The difference between 2 groups was determined by t-test or chi-square test for normally distributed variables and by Mann–Whitney U test for non-normally distributed variables.
