Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2018 (2018), Article ID 3502401, 8 pages
https://doi.org/10.1155/2018/3502401
Research Article

4-Hydroxy-2-nonenal Alkylated and Peroxynitrite Nitrated Proteins Localize to the Fused Mitochondria in Malpighian Epithelial Cells of Type IV Collagen Drosophila Mutants

1Institute of Medical Biology, University of Szeged, Somogyi B. U. 4, 6720 Szeged, Hungary
2John A. Burns School of Medicine, University of Hawaii, 1960 East West Road, Honolulu, HI 96822, USA

Correspondence should be addressed to Mátyás Mink; uh.degezs-u.oib@knim

Received 4 September 2017; Revised 3 December 2017; Accepted 2 January 2018; Published 30 January 2018

Academic Editor: Daniela Grifoni

Copyright © 2018 András A. Kiss et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Pozzi, P. D. Yurchenco, and R. V. Iozzo, “The nature and biology of basement membranes,” Matrix Biology, vol. 57-58, pp. 1–11, 2017. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Jeanne and D. B. Gould, “Genotype-phenotype correlations in pathology caused by collagen type IV alpha 1 and 2 mutations,” Matrix Biology, vol. 57-58, pp. 29–44, 2017. View at Publisher · View at Google Scholar · View at Scopus
  3. D. S. Kuo, C. Labelle-Dumais, and D. B. Gould, “COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets,” Human Molecular Genetics, vol. 21, no. 1, pp. R97–R110, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. Z. Chen, T. Migeon, M.-C. Verpont et al., “HANAC Syndrome Col4a1 Mutation Causes Neonate Glomerular Hyperpermeability and Adult Glomerulocystic Kidney Disease,” Journal of the American Society of Nephrology : JASN, vol. 27, no. 4, pp. 1042–1054, 2016. View at Publisher · View at Google Scholar · View at Scopus
  5. I. Kelemen-Valkony, M. Kiss, J. Csiha et al., “Drosophila basement membrane collagen col4a1 mutations cause severe myopathy,” Matrix Biology, vol. 31, no. 1, pp. 29–37, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. I. Kelemen-Valkony, M. Kiss, K. Csiszár, and M. Mink, Inherited Myopathies, Nova Publishers, New York, NY, USA, 2012.
  7. M. Kiss, A. A. Kiss, M. Radics et al., “Drosophila type IV collagen mutation associates with immune system activation and intestinal dysfunction,” Matrix Biology, vol. 49, pp. 120–131, 2016. View at Publisher · View at Google Scholar
  8. F. J. Schopfer, P. R. S. Baker, and B. A. Freeman, “NO-dependent protein nitration: A cell signaling event or an oxidative inflammatory response?” Trends in Biochemical Sciences, vol. 28, no. 12, pp. 646–654, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Denicola and R. Radi, “Peroxynitrite and drug-dependent toxicity,” Toxicology, vol. 208, no. 2, pp. 273–288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. S. N. A. Hussain, G. Matar, E. Barreiro, M. Florian, M. Divangahi, and T. Vassilakopoulos, “Modifications of proteins by 4-hydroxy-2-nonenal in the ventilatory muscles of rats,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 290, no. 5, pp. L996–L1003, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Dalleau, M. Baradat, F. Guéraud, and L. Huc, “Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance,” Cell Death & Differentiation, vol. 20, no. 12, pp. 1615–1630, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Juric-Sekhar, K. Zarkovic, G. Waeg, A. Cipak, and N. Zarkovic, “Distribution of 4-hydroxynonenal-protein conjugates as a marker of lipid peroxidation and parameter of malignancy in astrocytic and ependymal tumors of the brain,” TUMORI, vol. 95, no. 6, pp. 762–768, 2009. View at Google Scholar · View at Scopus
  13. K. M. Nash, A. Rockenbauer, and F. A. Villamena, “Reactive nitrogen species reactivities with nitrones: Theoretical and experimental studies,” Chemical Research in Toxicology, vol. 25, no. 8, pp. 1581–1597, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. J. A. T. Dow and M. F. Romero, “Drosophila provides rapid modeling of renal development, function, and disease,” American Journal of Physiology-Renal Physiology, vol. 299, no. 6, pp. F1237–F1244, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. K. W. Beyenbach and P. L.-F. Liu, “Mechanism of fluid secretion common to aglomerular and glomerular kidneys,” Kidney International, vol. 49, no. 6, pp. 1543–1548, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. A. A. Kiss, N. Popovics, G. Szabó, K. Csiszár, and M. Mink, “Altered stress fibers and integrin expression in the Malpighian epithelium of Drosophila type IV collagen mutants,” Data in Brief, vol. 7, pp. 868–872, 2016. View at Publisher · View at Google Scholar · View at Scopus
  17. D. R. LaJeunesse, S. M. Buckner, J. Lake, C. Na, A. Pirt, and K. Fromson, “Three new Drosophila markers of intracellular membranes,” BioTechniques, vol. 36, no. 5, pp. 784–790, 2004. View at Google Scholar · View at Scopus
  18. R. Radi, “Nitric oxide, oxidants, and protein tyrosine nitration,” Proceedings of the National Acadamy of Sciences of the United States of America, vol. 101, no. 12, pp. 4003–4008, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Chien, L. T. Reiter, E. Bier, and M. Gribskov, “Homophila: Human disease gene cognates in Drosophila,” Nucleic Acids Research, vol. 30, no. 1, pp. 149–151, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Fu, J.-Y. Zhu, A. Richman et al., “A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome,” Human Molecular Genetics, vol. 26, no. 4, pp. 768–780, 2017. View at Publisher · View at Google Scholar · View at Scopus
  21. E. Plaisier, O. Gribouval, S. Alamowitch et al., “COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps,” The New England Journal of Medicine, vol. 357, no. 26, pp. 2687–2695, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Weng, D. J. Dilworth, R. T. Libby, S. W. John, and D. B. Gould, “Mutant COL4A1 triggers oxidative stress in a genetic model of AMD,” Matrix Biology, vol. 27, p. 39, 2008. View at Publisher · View at Google Scholar
  23. R. J. Youle and A. M. van der Bliek, “Mitochondrial fission, fusion, and stress,” Science, vol. 337, no. 6098, pp. 1062–1065, 2012. View at Publisher · View at Google Scholar · View at Scopus