Chemoradiotherapy as Definitive Treatment for Elderly Patients with Head and Neck Cancer

Table 4

Univariate and multivariate analysis of clinicopathological parameters regarding overall survival (OS), progression-free survival (PFS), local control rate (LCR), and distant metastasis-free survival (DMFS); for 135/158 patients available; for 116/158 patients available.

Categories	Univariate analysis
	OS			PFS			LCR			DMFS
	HR	CI 95%	p value	HR	CI 95%	p value	HR	CI 95%	p value	HR	CI 95%	p value
p16 status; neg/po	1.65	0.83–3.28	0.153	2.351	0.996–5.548	0.051	2.088	0.811–5.371	0.127	6.044	0.806–45.305	0.08
Smoker/non	1.846	1.054–3.233	0.032	1.503	0.777–2.906	0.226	1.387	0.664–2.895	0.384	2.840	1.029–7.835	0.044
Sex male/female	1.008	0.577–1.763	0.977	1.271	0.691–2.339	0.44	1.004	0.496–2.035	0.99	1.364	0.532–3.496	0.518
T3-4/T1-2	1.125	0.453–2.792	0.8	1.192	0.430–3.303	0.736	1.068	0.331–3.453	0.912	2.474	0.730–8.369	0.146
N3/N2/N0-1	2.004	1.098–3.659	0.024	2.002	1.008–3.974	0.047	1.498	0.732–3.062	0.268	3.104	1.016–9.483	0.047
G3/G2/G1	0.75	0.480–1.172	0.206	0,869	0.511–1.478	0.604	0,804	0.445–1.454	0.471	1.518	0.680–3.387	0.309
ECOG2-3/ECOG0-1	2.303	1258–4.129	0.005	2.092	1.060–4.129	0.033	2.589	1.246–5.380	0.011	1.550	0.521–4.615	0.431
Age < 65/≥65	0.895	0.558–1.436	0.646	1.310	0.737–2.327	0.357	1.131	0.606–2.110	0.699	0.651	0.255–1.666	0.371
Age < 70/≥70	0.912	0.524–1.589	0.746	1.057	0.545–2.049	0.871	0.892	0.441–1.806	0.751	0.59	0.174–1.994	0.396
Age < 75/≥75	0.87	0.417–1.814	0.71	1.069	0.426–2.684	0.887	0.833	0.328–2.115	0.701	0.918	0.214–3.932	0.909
Categories	Multivariate analysis
	OS			PFS			LCR			DMFS
	HR	CI 95%	p value	HR	CI 95%	p value	HR	CI 95%	p value	HR	CI 95%	p value
Smoker/nonsmoke	2.321	1.287–4.183	0.005							3.222	1.130–9.189	0.029
N3/N2/N0-1	2.356	0.947–5.863	0.066	1.819	0.859–3.852	0.118				6.890	1.479–32.109	0.014
ECOG2-3/ECOG0-1	2.573	1.344–4.928	0.004	1.990	1.007–3.933	0.048