Cinnamaldehyde Improves Lifespan and Healthspan in Drosophila melanogaster Models for Alzheimer’s Disease

Figure 3

The effect of 80 mM of cinnamaldehyde on the lifespan of non-Alzheimer’s disease (AD) parental control flies. (a, b) Cinnamaldehyde significantly increased the lifespan of male parental control flies by 5.4% (male control n = 115, male CM n = 110, P = 0.01) and females by 39.9% (female control n = 109, female CM n = 111, P < 0.0001). (c) Cinnamaldehyde had no effect on the lifespan of non-AD MAPT parental control males (male control n = 113, male CM n = 84, P > 0.05). (d) Cinnamaldehyde increased the lifespan of non-AD MAPT parental control females by 30.9% (female control n = 121, female CM n = 104, P < 0.0001). (e) Cinnamaldehyde increased the lifespan of non-AD Aβ₄₂ parental control males (male control n = 110, male CM n = 109, P < 0.0001). (f) Cinnamaldehyde had no effect on the lifespan of non-AD MAPT parental control females (female control n = 110, female CM n = 104, P > 0.05).

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