Bioinformatical Analysis of Organ-Related (Heart, Brain, Liver, and Kidney) and Serum Proteomic Data to Identify Protein Regulation Patterns and Potential Sepsis Biomarkers

Figure 3

Heat map of the hierarchical cluster analysis of significantly regulated serum proteins. Two subclusters with significantly upregulated proteins at 12 or 12 and 24 hours are highlighted. A brick can progressively become darker up to a completely black one that would represent a fold change equal to 1 (therefore, no change between sepsis and sham groups). On the contrary, a green brick represents a protein whose expression at a particular time was decreased when compared to the value of the same protein in the sham group at that time.