Research Article
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates
Table 5
Mutations on blaC, ldtMt1, ldtMt2, and dacB2 genes.
| | Gene | Substitution | Amino acid change | Number of mutants |
| | blaC | G183A | Leu61Leu | 1 | | | T333G | Ser111Arg | 3 | | | C354T | Ser118Ser | 1 | | | G486C | Ala162Ala | 1 | | | T492A | Phe164Leu | 1 | | | G514A | Gly172Ser | 1 | | | C610T | Leu204Leu | 1 | | | C786T | Ile262Ile | 11 | | ldtMt1 | A111G | Pro37Pro | 1 | | | G448A | Ala150Thr | 1 | | | C659T | Ala220Val | 2 | | ldtMt2 | C594T | Gly198Gly | 1 | | | A776G | Asp259Gly | 4 | | dacB2 | T659A | Leu220Gln | 4 |
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