BioMed Research International / 2018 / Article / Tab 1

Research Article

Inhibitory Effects of Compounds and Extracts from Ampelopsis brevipedunculata on IL-6-Induced STAT3 Activation

Table 1

Inhibitory effects of the major compounds from Ampelopsis brevipedunculata on IL-6/STAT3 activation.

CompoundIC50 (μM)CompoundIC50 (μM)

Betulin (1)3.12 ± 0.31Ethyl gallate (10)44.13 ± 3.16
Betulinic acid (2)6.98 ± 0.34Ethyl gallyl 4-O-α-D-glucopyranoside (11)22.85 ± 0.74
β-Sitosterol (3)> 50Syringic acid (12)15.82 ± 4.70
β-Sitosterol glucoside (4)> 50Benzyl 6′-O-galloyl-β-D-glucopyranoside (13)4.99 ± 2.02
Aromadendrin (5)49.73 ± 10.15Ellagic acid (14)4.85 ± 1.73
3-O-Glycoside-aromadendrin (6)> 503′-O-Methylellagic acid 4-O-α-L-rhamnopyranoside (15)> 50
Catechin (7)> 504′-O-(β-D-Glucopyranosyl)-3,3′4-tri-O-methylellagic acid (16)> 50
Gallic acid (8)27.30 ± 3.58Resveratrol (17)21.18 ± 1.10
Vanillic acid (9)> 5013.60 ± 0.36

Genistein was used as the positive control.