Novel Intravaginal Drug Delivery System Based on Molecularly PEGylated Lipid Matrices for Improved Antifungal Activity of Miconazole Nitrate

Table 5

MICs and MFCs of optimized miconazole nitrate-loaded SLMs.

Formulation code	MIC (μg/ml)	MFC (μg/ml)
AM3	29.297 ± 2.65	468.754 ± 5.06
BM3	14.648 ± 0.98	234.375 ± 4.33
CM3	7.324 ± 1.32	117.188 ± 2.19
DM3	14.648 ± 3.08	234.375 ± 4.25
MN pure sample suspension	58.594 ± 4.11	937.500 ± 3.11
Fungusol® lotion	29.297 ± 2.22	468.754 ± 6.00

Key: MIC and MFC are minimum inhibitory concentration and minimum fungicidal concentration; AM₃ is optimized non-PEGylated SLMs containing 3.0 %w/w of miconazole nitrate; BM₃–DM₃ are PEGylated SLMs containing increasing concentrations (1.0, 2.0, and 4.0 %w/w) of PEG 4000, respectively, and 3.0 %w/w of miconazole nitrate; Fungusol® is commercial topical formulation of miconazole nitrate, while MN is pure miconazole nitrate sample.