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BioMed Research International
Volume 2018, Article ID 3808675, 6 pages
Research Article

Reduction of Pulmonary Air Leaks with a Combination of Polyglycolic Acid Sheet and Alginate Gel in Rats

1Medical Life System, Faculty of Life and Medical Science, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan
2Fushimi Okamoto Hospital, 9-50 Kyomachi, Hushimi-Ku, Kyoto, Kyoto 612-8083, Japan
3Kusatsu General Hospital, 1660 Yabase-cho, Kusatsu, Shiga 525-8585, Japan
4Kainan Hospital, 396 Minamihonden, Maegasu-cho, Yatomi, Aichi 498-8502, Japan

Correspondence should be addressed to Akeo Hagiwara; pj.en.tenoe.suez@8011.aniram

Received 2 October 2017; Accepted 11 December 2017; Published 2 January 2018

Academic Editor: Torsten Goldmann

Copyright © 2018 Mari Matoba et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Postoperative air leaks remain a major cause of morbidity after lung resection. This study evaluated the effect of a combination of polyglycolic acid (PGA) sheet and alginate gel on pulmonary air leaks in rats. Four pulmonary sealing materials were evaluated in lung injury: fibrin glue, combination of PGA sheet and fibrin glue, alginate gel, and combination of PGA sheet and alginate gel. With the airway pressure maintained at 20 cmH2O, a 2 mm deep puncture wound was created on the lung surface using a needle. Lowering the airway pressure to 5 cmH2O, each sealing material was applied. The lowest airway pressure that broke the seal was measured. The seal-breaking pressure in each experimental group was fibrin,  cmH2O; PGA + fibrin,  cmH2O; alginate gel,  cmH2O; and PGA + alginate,  cmH2O, respectively. The seal-breaking pressure was significantly greater in the PGA + alginate gel group than in the other groups (). There were no significant differences among the other three groups. Alginate gel combined with a PGA sheet is a promising alternative to fibrin glue as a safe and low-cost material for air leak prevention in pulmonary surgery.