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BioMed Research International
Volume 2018, Article ID 3819719, 6 pages
Review Article

Physiological and Pathological Function of Serine/Arginine-Rich Splicing Factor 4 and Related Diseases

1Department of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China
2Department of Clinical Laboratory, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3Medical Research Institute, Kanazawa Medical University, Ishikawa 920-0293, Japan

Correspondence should be addressed to Qingfeng Ma;

Received 13 September 2017; Revised 3 January 2018; Accepted 17 January 2018; Published 12 February 2018

Academic Editor: Graziano Pesole

Copyright © 2018 Wanyan Tan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Serine/arginine-rich splicing factors (SRSFs) have one or two RNA recognition motifs in the N terminal and a serine/arginine-enriched domain in the C terminal. SRSFs are essential components of spliceosomes and are involved in alternative splicing, spliceosome assembly, mRNA export, and nonsense-mediated mRNA decay. The maintenance of cellular and tissue homeostasis relies on accurate alternative splicing, and various patterns of abnormal alternative splicing can cause different diseases. SRSF4 is associated with many physiological and pathological processes and has applications in the diagnosis and prognosis of specific diseases. In this review, we discuss knowledge of SRSF4 in physiological and pathological processes and highlight the applications of SRSF4 in the regulation of gene expression and associated diseases.