In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species

Table 1

The treatment groups in each animal test. Each treatment group contains 6 animals (). All treatments were administered intraperitoneally (i.p.).

Treatment groups	Toxicity testing	Acetic acid induced writhing test	Inclined plan test/traction test	Sedative activity
Normal Saline	10 ml/kg	10 ml/kg	10 ml/kg	10 ml/kg
Reference group	- - - - -	Diclofenac (10 mg/kg)	Diazepam (1 mg/kg)	Diazepam (0.5 mg/kg)
Crude extract	250 mg/kg	25 mg/kg	25 mg/kg	25 mg/kg
	500 mg/kg	50 mg/kg	50 mg/kg	50 mg/kg
	1000 mg/kg	100 mg/kg	100 mg/kg	100 mg/kg
n-Hexane fraction	250 mg/kg	25 mg/kg	25 mg/kg	25 mg/kg
	500 mg/kg	50 mg/kg	50 mg/kg	50 mg/kg
	1000 mg/kg	100 mg/kg	100 mg/kg	100 mg/kg
Chloroform fraction	250 mg/kg	25 mg/kg	25 mg/kg	25 mg/kg
	500 mg/kg	50 mg/kg	50 mg/kg	50 mg/kg
	1000 mg/kg	100 mg/kg	100 mg/kg	100 mg/kg
Ethyl acetate fraction	250 mg/kg	25 mg/kg	25 mg/kg	25 mg/kg
	500 mg/kg	50 mg/kg	50 mg/kg	50 mg/kg
	1000 mg/kg	100 mg/kg	100 mg/kg	100 mg/kg