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BioMed Research International
Volume 2018, Article ID 3921247, 7 pages
Review Article

Salivary Biomarkers in Systemic Sclerosis Disease

Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaâdi University, Tetouan, Morocco

Correspondence should be addressed to Zeineb Zian;

Received 19 October 2017; Revised 14 January 2018; Accepted 11 February 2018; Published 12 March 2018

Academic Editor: Fernando C. e Silva

Copyright © 2018 Zeineb Zian et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Scleroderma or systemic sclerosis (SSc) is frequently detected at an advanced stage due to diagnosis difficulties. Salivary biomarkers, if existing, could be used for predictive diagnosis of this disease. Human saliva contains a large number of proteins that can be used for diagnosis and are of great potential in clinical research. The use of proteomic analysis to characterize whole saliva (WS) in SSc has gained an increasing attention in the last years and the identification of salivary proteins specific for SSc could lead to early diagnosis or new therapeutic targets. This review will present an overview about the use of WS in SSc studies. The proteomic technologies currently used for global identification of salivary proteins in SSc, as well as the advantages and limitations for the use of WS as a diagnostic tool, will be presented.