Review Article | Open Access
Chun-Ye Chen, Qing-Qing Fang, Xiao-Feng Wang, Min-Xia Zhang, Wan-Yi Zhao, Bang-Hui Shi, Li-Hong Wu, Li-Yun Zhang, Wei-Qiang Tan, "Madelung’s Disease: Lipectomy or Liposuction?", BioMed Research International, vol. 2018, Article ID 3975974, 8 pages, 2018. https://doi.org/10.1155/2018/3975974
Madelung’s Disease: Lipectomy or Liposuction?
Background. Madelung’s disease is a rare lipid metabolic disorder characterized by diffuse, uncapsulated lipomas in the neck, shoulder, and other areas. It mainly affects middle-aged men and is related to alcohol abuse, and the cause is not clear. Surgical treatments include lipectomy and liposuction. Methods. This systematic review analyzed the treatment of Madelung’s disease described in 52 articles including complete patient details, published between 2000 and 2015, and retrieved from the Web of Science, PubMed, Medline, and Embase. Results. Lipectomy was performed in most cases and achieved more complete removal and better control of iatrogenic lesions of nearby structures than liposuction. Liposuction achieved good cosmetic results and is simpler and less invasive than lipectomy, but clinical experience is limited. Conclusions. Both lipectomy and liposuction have advantages and drawbacks. Surgeons should base the choice of optimal treatment on patient characteristics. Novel surgical techniques and etiologically targeted treatments hold promise as future therapies.
Madelung’s disease, multiple symmetrical lipomatosis, or benign symmetric lipomatosis is a rare disorder of adipose metabolism that was first reported in 1846 by Benjamin Brodie. It presents with multiple, symmetrical, nonencapsulated fatty masses in the maxillofacial region, neck, shoulder, trunk, limbs, and other areas. In most patients, neck involvement results in a specific sign called Madelung’s or horse collar [1, 2]. Madelung’s disease is more common in middle-aged men of Mediterranean origin and is related to alcohol abuse. However, cases have been reported in women, patients in south east countries, and in nondrinkers [1–3].
The disease is not painful; most but not all cases have a slow clinical course , and malignant transformation is infrequent [1, 2]. Transformation to intramyxoid sarcoma after a 6-year follow-up was reported by Tizian; a case of liposarcoma transformation was reported by Sia et al. [3–5]. Cosmetic deformity and compression symptoms such as dyspnea and dysphagia are indications for treatment. Comorbidities such as liver cirrhosis, nephropathy, neuropathy, and metabolic disorders have been reported [1–3], but no causal relationships between those disorders and Madelung’s disease have been established . Two types of Madelung’s disease can be distinguished by their clinical characteristics [1, 2, 6]. Type I occurs most often in men, generally as a symmetrical distribution of superficial fatty masses with a “pseudoathletic” appearance, which are likely to cause compression symptoms. Type II can occur in both men and women, with a presentation similar to generalized obesity. The classification is not very exacting.
The etiology of Madelung’s disease has not been established, but recent evidence has implicated mitochondrial dysfunction resulting from mutations of mitochondrial DNA [1, 2, 7] and changes in enzyme and membrane receptor activity that reduce adrenergic-mediated lipolysis. Alcohol consumption might serve as a predisposing or aggravating factor . The diagnosis can made by clinical features and imaging studies . Computed tomography, ultrasonography, and magnetic resonance imaging determine the adhesion to, size, location, and compression of adjacent tissue. Imaging thus helps with the diagnosis, differential diagnosis, and preoperative assessment [2, 8]. The use of magnetic resonance imaging for assessment and preoperative planning has been recently reviewed in a case report by Sharma et al. . Histologically, the adipocytes present in the fatty masses in Madelung’s disease are smaller, and the content of fibrous and vascular tissues is greater than normal . There is also a loss of large myelinated cells, but without the demyelination or axonal degeneration induced by chronic alcohol ingestion . At least one report found that the triglyceride content of fat cells was affected . This systematic review summarizes the current treatment of Madelung’s disease and the choice of treatment in different clinical contexts.
2.1. Literature Search
This systematic review followed the PRISMA guidelines. The Web of Science, PubMed, Medline, and Embase were searched for case reports of Madelung’s disease published from 2000 to 2015. The search terms were “Madelung disease,” “Madelung syndrome,” “multiple symmetrical lipomatosis,” and “benign symmetric lipomatosis.” Duplicate publications, meeting abstracts, treatment guidelines, recommendations, literature reviews without case reports, experimental animal model studies, etiologic investigations, and cases reports without clear clinical data including patient age, sex, symptoms, and treatment were excluded.
A total of 52 studies published from 2000 to 2015 included complete patient characteristics and treatment descriptions and were selected for review [1–3, 8, 10–57]. The studies are listed in Table 1. For ease of understanding, the clinical characteristics and treatment methods of these patients with Madelung’s disease are summarized in Table 2.
A total of 41 studies published from 2005 to 2015 included complete patient characteristics and treatment descriptions and were selected for review [1–3, 8, 10–57]. This patient had a relapse 4 years after treatment, then surgical procedure was performed, and there was no recurrence of the lipomatosis after a 32-month follow-up. The lipomatosis of 2 patients remained unchanged in 4-month to 3-year follow-up. These 2 patients both had successful previous surgical excision. This patient had failed liposuction before. Patients in these cases were submitted to liposuction combined with lipectomy. Malignant happened in this case.
A simple summary of the clinic date of the 106 published cases of Madelung’s disease.
3.1. Characteristics of Reported Cases
The average age of the 106 reported cases from the 52 studies (Table 1) was 52.9 years, and the male-to-female ratio was 93 : 13. The majority of masses were located on the neck and face, but the trunk and limbs are also common sites. Lipomas were rarely reported around the eye or on the tongue, throat, breast, pubis, and testis. The most frequent comorbidities were nephropathy, hepatopathy, and metabolic abnormalities. Klinefelter syndrome, acquired immunodeficiency syndrome, and sexual dysfunction were rarely reported comorbidities.
Surgery was the most frequent treatment, 8.49% of the patients were treated medically. Intralipotherapy was used in three patients (2.86%) described in two reports. One intralipotherapy patient (Table 1a) had a recurrence 4 years after treatment. It was treated surgically without a second recurrence at 32 months of follow-up . The other two patients (Table 1c) had both experienced a successful prior surgical excision . And this study showed that intralipotherapy achieved a 2.5% reduction in average size and had a 33% recurrence rate . Medical therapy was described in five reports. Lipomatosis remained unchanged in two of those patients (Table 1b) after 4 months to 3 years of follow-up [14, 32]. The other three studies did not report whether any relapses had occurred.
Ninety-five patients (89.62%) were treated surgically by lipectomy, and 79 of them were treated by lipectomy only. Four of those 79 patients experienced relapses, one experienced malignant transformation (Table 1f) , and 30 patients with reported follow-up did not experience a relapse. Whether or not relapse occurred was not reported for 24 patients. One surgery patient (Table 1d) had failed liposuction . Only 18 patients (16.98%) were treated by liposuction, and 2 of them were treated by liposuction only: one experienced relapse after 1 year of follow-up , and the other case was not mentioned. Sixteen of the 18 patients experienced procedures that were combined with lipectomy (Table 1e) [23, 43, 47, 54, 56]. Two of the 16 patients experienced relapse after 1 and 1.5 years of follow-up .
3.2. Synthesis of Results
Table 2 summarizes the clinical characteristics of the published cases of Madelung’s disease. Most patients were middle-aged men, and the most frequent locations were on the neck and face. The most frequent comorbidities were nephropathy, hepatopathy, and metabolic abnormalities. Most patients were treated surgically by lipectomy and a few by liposuction. Medical procedures were seldom used and included mainly intralipotherapy. Novel techniques included combined lipectomy and liposuction, ultrasound-assisted liposuction, tunneling techniques, cervical dissection techniques, powered-assisted liposuction, and a rhytidectomy approach. The main treatment-related problem was relapse, especially following liposuction.
Treatment for Madelung’s disease included both surgical and nonsurgical procedures. Surgical treatment was the most frequent treatment and included lipectomy and liposuction.
4.1. Nonsurgical Treatment
Some reports recommended intralipotherapy as a noninvasive treatment of Madelung’s disease, in which the mass was injected with phosphatidylcholine/deoxycholate. Scevola et al. confirmed the efficacy of intralipotherapy after long-term assessment . Intralipotherapy mainly limits the growth of adipose masses and is not highly effective in reducing their volume. If surgical dissection is planned, then surgeons should be aware of the potential for adhesions in patients who were previously treated with injection lipolysis . Abstinence from alcohol may slow the enlargement of adipose masses but cannot reverse the disease. The risk of recurrence is decreased by abstaining from alcohol after surgery. Other lifestyle modifications that improve blood glucose and lipid control in patients with comorbidities may prevent growth of adipose masses but do not reduce their size . Dietary management does not help . Other therapeutic methods such as injecting lesions with enoxaparin and β2 agonists  may be effective, but their curative effects have not been clearly demonstrated.
Lipectomy and liposuction are the most effective surgical options, but because the etiology of Madelung’s disease is not clear, they are seen as palliative surgery . Lipectomy was performed in most reported cases, allowing for satisfactory exposure and allowing for complete removal with good control of iatrogenic lesions of nearby structures, especially vessels and nerves. Although direct visualization reduces the risk of injury, lipectomy is not technically easy because the lipomas are nonencapsulated with wide infiltration of surrounding tissue [2, 58]. During surgery, the pathological hyperplastic lipoma is difficult to distinguish from subcutaneous fat and other healthy tissues . Lipectomy has disadvantages of an increased rate of surgical complications including infection, hemorrhage, hematoma, lymphatic fistula, and pathologic scarring [1, 2, 8, 58]. Although it is an open approach, debulking surgery has been recommended as allowing for a better cosmetic result than lipectomy, with the exception of scar formation . Most reports recommend a single transverse incision rather than multiple direct incisions to remove Madelung’s collar .
Liposuction has gained in popularity because it is less traumatic and has better cosmetic outcomes than surgery. However, because it has not been widely used, there is little clinical experience with liposuction in Madelung’s disease patients. The advantages of liposuction include simplicity, minimal invasiveness, and low morbidity; it has been an adjunct therapy in many cases. In addition, its dense and fibrous composition make it difficult to aspirate the fatty tissue in the conventional way [1, 2, 8], posing a problem for surgeons during liposuction. The nature of the adipose masses also decreases the reliability of preoperative assessment of possible liposuction failure. There are no histological assessments, like the extent of fibroplasia, that allow avoiding the difficulties of liposuction . It is difficult to achieve complete removal either by liposuction or lipectomy because the lipomas are nonencapsulated, making recurrence nearly unavoidable. Finally lipectomy and liposuction are not simple because growth of the fatty masses may proceed in more than one direction and involve several structures .
4.4. Indications for Surgical Treatment
As there is no definitive, etiologically targeted treatment, all treatments are palliative. The goal of treatment is recovery of function and improved appearance. It is not necessary to place patients at risk by performing premature, radical surgery for this benign disease . Lipectomy is considered the treatment of choice for Madelung’s disease, performed primarily in severe cases involving multiple body structures or producing compression symptoms . Lipectomy is necessary if there is obstruction of the trachea or pharynx leading to dyspnea, dysphagia, or related symptoms . Lipectomy is also indicated for treating severe deformities and for removal of redundant skin . Liposuction has been used to treat less severe cases with limited areas of involvement or as a second-stage or adjunct treatment. If the lipomas are very diffuse, making them difficult to remove by lipectomy, liposuction should be considered . Liposuction is also more suitable for patients at increased surgical and/or anesthetic risk . Some authors recommend that liposuction not be applied in the submental region or in regions with scars from previous surgery . Grassegger et al. reported the safe use of tumescent liposuction in patients with Madelung’s disease and liver cirrhosis. The patients had compensated disease, minor procedures, low total lidocaine doses, and careful postoperative surveillance .
4.5. Novel Techniques
Some revisions of standard lipectomy and liposuction treatment have been evaluated in Madelung’s patients. In 2003, Constantinidis et al. reported satisfactory outcomes using combined lipectomy and liposuction in 11 cases with masses in the head and neck region . Bassetto et al. described use of ultrasound-assisted liposuction to prevent injury to surrounding structures, such as blood vessels and nerves . This technique provided gentle, precise liposuction that reduced damage to subcutaneous tissue and vascular structures but had unsatisfactory cosmetic outcomes [3, 58]. With the tunneling technique, most subcutaneous neurovascular plexus remain intact, and the problem of redundant loose skin is also solved . Andou et al. reported a case in which improved lipectomy using a cervical dissection technique was helpful for treating Madelung’s collar . Tremp et al. found that tightening of the skin achieved by power-assisted liposuction improved cosmetic outcomes and was an effective method . Pinto et al. proposed a rhytidectomy approach for recurrent Madelung’s disease  using multiple-stage surgery. A small submental incision and slightly modified rhytidectomy incisions were made to access the anterior and lateral neck during the supine stage. A posterior neck incision was then made during the prone stage to optimize skin redraping and address the posterior neck hump . Pinto et al.  used an inverted T shaped incision (sagittal and suprasternal incisions) successfully, which offers good exposure and allows for removal of skin excesses.
The most effective treatments of Madelung’s disease were lipectomy and liposuction, both of which have advantages and drawbacks. Before surgery, patients should be informed of the risks and benefits of lipectomy and liposuction and be made aware of the risk of lipoma recurrence. The choice of surgical procedure depends on the disease extent, patient expectations, and the surgeon’s experience. This systematic review included a relatively small number of cases. Some clinical data was missing, and some reports were of rare cases that were not truly representative. Despite these limitations, the examples of successful treatment of Madelung’s disease provide alternatives for managing patients. Future trends in treatment of Madelung’s disease would benefit from study of its etiology and pathogenesis. Experience with modified techniques of liposuction or lipectomy should be expected to make treatment more effective.
Conflicts of Interest
The authors declare that there are no conflicts of interest regarding the publication of this article.
Chun-Ye Chen and Qing-Qing Fang contribute equally to this work.
This work was supported by grants from the National Natural Science Foundation of China (no. 81671918 and 81372072), the National Key Research Program of China (no. 2016YFC1101004), Zhejiang Provincial Science and Technology Project of China (no. 2016C33134), and Zhejiang Provincial Medical and Healthy Science Foundation of China (no. 2018KY874).
- G. Verna, N. Kefalas, F. Boriani, S. Carlucci, I. Choc, and M. A. Bocchiotti, “Launois-Bensaude syndrome: An unusual localization of obesity disease,” Obesity Surgery, vol. 18, no. 10, pp. 1313–1317, 2008.
- R. González-García, F. J. Rodriguez-Campo, J. Sastre-Pérez, and M. F. Muñoz-Guerra, “Benign symmetric lipomatosis (Madelung's disease): Case reports and current management,” Aesthetic Plastic Surgery, vol. 28, no. 2, pp. 108–112, 2004.
- K. J. Sia, I. P. Tang, and T. Y. Tan, “Multiple symmetrical lipomatosis: Case report and literature review,” The Journal of Laryngology & Otology, vol. 126, no. 7, pp. 756–758, 2012.
- C. Tizian, A. Berger, and K. F. Vykoupil, “Malignant degeneration in Madelung's disease (benign lipomatosis of the neck): case report,” British Journal of Plastic Surgery, vol. 36, no. 2, pp. 187–189, 1983.
- J. P. Durand, J. M. Thomine, J. Tayot et al., “Liposarcoma in a Launois-Bensaude disease,” French, vol. 40, pp. 287–291, 1973.
- S. Ramos, S. Pinheiro, C. Diogo, L. Cabral, and C. Cruzeiro, “Madelung disease: A not-so-rare disorder,” Annals of Plastic Surgery, vol. 64, no. 1, pp. 122–124, 2010.
- A. Grassegger, R. Häussler, and F. Schmalzl, “Tumescent liposuction in a patient with Launois-Bensaude syndrome and severe hepatopathy,” Dermatologic Surgery, vol. 33, no. 8, pp. 982–985, 2007.
- N. A. C. Verhelle, J.-L. Nizet, B. Van Den Hof, P. Guelinckx, and O. Heymans, “Liposuction in Benign Symmetric Lipomatosis: Sense or Senseless?” Aesthetic Plastic Surgery, vol. 27, no. 4, pp. 319–321, 2003.
- N. Sharma, D. J. Hunter-Smith, A. Rizzitelli et al., “A surgical view on the treatment of Madelung's disease,” Clinical Obesity, vol. 5, no. 5, pp. 288–290, 2015.
- M. Azuma, M. Adachi, M. Motohashi et al., “Symmetrical lipomatosis of the tongue: Case report and literature review,” Journal of Clinical Lipidology, vol. 9, no. 4, pp. 602–606, 2015.
- E. Andou, M. Komoto, T. Hasegawa, H. Mizuno, and A. Hayashi, “Surgical Excision of Madelung Disease Using Bilateral Cervical Lymphnode Dissection Technique—Its Effect and the Influence of Previous Injection Lipolysis,” Plastic and Reconstructive Surgery - Global Open, vol. 3, no. 4, p. e375, 2015.
- H. J. Kang, I. S. Lee, W. J. Cha et al., “Imaging Features of Madelung’s Disease: Case Report,” Investigative Magnetic Resonance Imaging, vol. 19, no. 2, pp. 122–126, 2015.
- B. Zielińska-Kaźmierska, M. Lewicki, and B. Manowska, “Madelung disease,” Postepy Dermatologii i Alergologii, vol. 32, no. 5, pp. 400–403, 2015.
- A. Ozderya, S. Temizkan, K. Aydin Tezcan, F. Y. Ozturk, and Y. Altuntas, “A case of Madelung's disease accompanied by Klinefelter's syndrome,” Endocrinology, Diabetes & Metabolism Case Reports, 2015.
- J. H. Jang, A. Lee, S.-A. Han, J.-K. Ryu, and J.-Y. Song, “Multiple symmetric lipomatosis (Madelung’s disease) presenting as bilateral huge gynecomastia,” Journal of Breast Cancer, vol. 17, no. 4, pp. 397–400, 2014.
- V. Celentano, E. Esposito, and S. Perrotta, “Madelung disease: report of a case and review of the literature,” Acta Chirurgica Belgica, vol. 114, no. 6, pp. 417–420, 2014.
- Z. Pinnella and J. Pinnella, “Facelift in a Patient With Benign Symmetric Lipomatosis and HIV Facial Lipoatrophy,” Annals of Plastic Surgery, vol. 73, no. 3, pp. 266-267, 2014.
- S. Scevola, G. Nicoletti, A. Neri et al., “Long term assessment of intralipotherapy in Madelung's disease,” Indian Journal of Plastic Surgery, vol. 47, no. 3, pp. 427–431, 2014.
- C. R. Orasmo, J. P. Ocanha, S. R. C. Barraviera, and H. A. Miot, “Syndrome in question,” Anais Brasileiros de Dermatologia, vol. 89, no. 3, pp. 525-526, 2014.
- G. Hundeshagen, G. Hundshagen, K. F. Assadov, and F. Podmelle, “Facelift- and circum-occipital incision placement for fat extirpation of the neck in Madelung's disease - A two-case report,” Journal of Cranio-Maxillo-Facial Surgery, vol. 42, no. 2, pp. 175–179, 2014.
- C.-J. Tai, C.-T. Huang, W.-C. Voon, and K.-T. Lee, “Madelung's disease mimicking deep vein thrombosis: An unusual case,” International Journal of Cardiology, vol. 172, no. 1, pp. e74–e75, 2014.
- Í. I. Shibasaki, H. I. Shibasaki, T. D. S. Nakamoto, F. S. Baccan, and L. S. Raposo, “Multiple symmetrical lipomatosis (Madelung's disease),” Brazilian Journal of Otorhinolaryngology, vol. 80, no. 1, pp. 90-91, 2014.
- T. Agostini, R. Perello, D. Bani, A. Mori, A. Quattrini Li, and G. L. Russo, “Histomorphometry of dystrophic fat in a patient suffering Madelung's disease,” Journal of Plastic, Reconstructive & Aesthetic Surgery, vol. 67, no. 1, pp. 132–134, 2014.
- Ž. S. Nikolić, J. V. Jeremić, L. J. Drčić et al., “Madelung disease: a rare case associated with gynaecomastia and scrotal involvement,” Journal of Plastic Surgery and Hand Surgery, vol. 47, no. 5, pp. 415–418, 2013.
- J. W. Kang and J. H. Kim, “Images in clinical medicine. Symmetric lipomatosis of the tongue.,” The New England Journal of Medicine, vol. 369, no. 4, p. e5, 2013.
- V. Ardeleanu, S. Chicos, C. Georgescu, and D. Tutunaru, “Multiple benign symmetric lipomatosis - A differential diagnosis of obesity,” Chirurgia (Romania), vol. 108, no. 4, pp. 580–583, 2013.
- K. Klobucnikova, I. Mucska, and B. Kollár, “A rare cause of obstructive sleep apnoea syndrome - Morbus madelung. Case reports,” Ceska a Slovenska Neurologie a Neurochirurgie, vol. 76, no. 2, pp. 235–240, 2013.
- M. Borriello, A. Lucidi, A. Carbone, V. Iannone, and G. Ferrandina, “Malignant transformation of Madelung's disease in a patient with a coincidental diagnosis of breast cancer: A case report,” Diagnostic Pathology, vol. 7, no. 1, article no. 116, 2012.
- C.-H. Lee, K.-T. Kang, J.-Y. Ko, and W.-H. Chang, “Laryngeal involvement in Madelung's disease with acute airway compromise,” Kaohsiung Journal of Medical Sciences, vol. 28, no. 8, pp. 462-463, 2012.
- M. Subash, A. Aziz, M. O'Doherty, and J. M. Olver, “Lipomatosis of the orbits: Possibly a form of Madelung's disease,” Eye (Basingstoke), vol. 26, no. 6, pp. 894-895, 2012.
- C. Friedl, E. Sampl, E.-C. Prandl et al., “Osteoporosis, weight gain and atypical fat accumulations - A typical feature not only for Cushing's, but also Madelung's disease: A case report,” Wiener Klinische Wochenschrift, vol. 124, no. 5-6, pp. 188–192, 2012.
- A. Tufan, R. Mercan, A. Kaya et al., “An Unusual Case of Madelung's Disease with Multiple Atypical Fractures,” Case Reports in Orthopedics, vol. 2012, pp. 1–3, 2012.
- E. Mevio, M. Sbrocca, M. Mullace, S. Viglione, and N. Mevio, “Multiple Symmetric Lipomatosis: A Review of 3 Cases,” Case Reports in Otolaryngology, vol. 2012, pp. 1–4, 2012.
- M. Di Candia and G. C. Cormack, “Rhytidectomy approach for recurrent madelung disease,” Aesthetic Surgery Journal, vol. 31, no. 6, pp. 643–647, 2011.
- S. Albu, “Madelung disease,” Ent-Ear Nose & Throat Journal, vol. 90, no. 4, pp. 148-149, 2011.
- D.-H. Lee, S.-C. Lim, and J. K. Lee, “Laryngeal involvement in madelung disease,” Otolaryngology—Head and Neck Surgery, vol. 144, no. 3, pp. 481-482, 2011.
- L. Ampollini and P. Carbognani, “Madelung's disease,” The New England Journal of Medicine, vol. 364, no. 5, p. 465, 2011.
- D. Milisavljevic, M. Zivic, Z. Radovanović, and P. Stankovic, “Severe dyspnea as atypical presenting symptom of Madelung's disease,” Hippokratia, vol. 14, no. 2, pp. 133–135, 2010.
- M. Juric and M. Carapina, “A case repot of Madelung's disease in a 69 years old man,” Collegium Antropologicum, vol. 33, suppl 2, pp. 169–171, 2009.
- Y. A. Alameda, L. Torres, C. Perez-Mitchell, and A. Riera, “Madelung disease: A clinical diagnosis,” Otolaryngology—Head and Neck Surgery, vol. 141, no. 3, pp. 418-419, 2009.
- A. Tekin and Z. Ogetman, “Central form of multiple symmetric lipomatosis: A case report,” Cases Journal, vol. 2, no. 8, article no. 8427, 2009.
- S. Y. Lee, C. W. Jeon, and S. J. Lee, “Benign Symmetrical Lipomatosis (Madelung's Disease),” Journal of the American College of Surgeons, vol. 208, no. 1, p. 164, 2009.
- O. Tan and D. Ergen, “Madelung syndrome with pubic involvement,” Dermatologic Surgery, vol. 34, no. 6, pp. 811–814, 2008.
- T. Bulum, L. Duvnjak, N. Car, and Ž. Metelko, “Madelung's disease: Case report and review of the literature,” Diabetologia Croatica, vol. 36, no. 2, pp. 25–30, 2007.
- S. Ali and A. Kishore, “Dysphagia and obstructive sleep apnoea in Madelung's disease,” The Journal of Laryngology & Otology, vol. 121, no. 4, pp. 398–400, 2007.
- A. Lopez-Ceres, Y. Aguilar-Lizarralde, A. Villalobos Sánchez, E. Prieto Sánchez, and A. Valiente Alvarez, “Benign symmetric lipomatosis of the tongue in Madelung's disease,” Journal of Cranio-Maxillo-Facial Surgery, vol. 34, no. 8, pp. 489–493, 2006.
- J. P. Conroy, “Airway management: A patient with Madelung disease,” AANA Journal, vol. 74, no. 4, pp. 281–284, 2006.
- G. Colella, A. Giudice, and A. Moscariello, “A case of Madelung's disease,” Journal of Oral and Maxillofacial Surgery, vol. 63, no. 7, pp. 1044–1047, 2005.
- J. Constantinidis, H. Steinhart, J. Zenk, H. Gassner, and H. Iro, “Combined surgical lipectomy and liposuction in the treatment of benign symmetrical lipomatosis of the head and neck,” Journal of Plastic Surgery and Hand Surgery, vol. 37, no. 2, pp. 90–96, 2003.
- V. Uglešić, P. Knežević, M. Milić, D. Jokić, and D. Košutić, “Madelung syndrome (benign lipomatosis): clinical course and treatment,” Journal of Plastic Surgery and Hand Surgery, vol. 38, no. 4, pp. 240–243, 2004.
- C. Guastella, C. Borsi, S. Gibelli, and L. G. Della Berta, “Madelung's lipomatosis associated with head and neck malignant neoplasia: A study of 2 cases,” Otolaryngology—Head and Neck Surgery, vol. 126, no. 2, pp. 191-192, 2002.
- M. Ujpaál, Z. S. Neémeth, A. Reichwein, and G. Y. Szaboó, “Long-term results following surgical treatment of benign symmetric lipomatosis (BSL),” International Journal of Oral and Maxillofacial Surgery, vol. 30, no. 6, pp. 479–483, 2001.
- A. Faga, L. A. Valdatta, A. Thione, and M. Buoro, “Ultrasound assisted liposuction for the palliative treatment of Madelung's disease: A case report,” Aesthetic Plastic Surgery, vol. 25, no. 3, pp. 181–183, 2001.
- S. Nielsen, J. Levine, R. Clay, and M. D. Jensen, “Adipose tissue metabolism in benign symmetric lipomatosis,” The Journal of Clinical Endocrinology & Metabolism, vol. 86, no. 6, pp. 2717–2720, 2001.
- M. Fischer, J. Wohlrab, K.-M. Taube, and W. C. Marsch, “Intralesional injection of enoxaparin in benign symmetrical lipomatosis: An alternative to surgery?” British Journal of Dermatology, vol. 144, no. 3, pp. 629-630, 2001.
- C. E. Payne, “Hereditary Madelung's disease,” Journal of the Royal Society of Medicine, vol. 93, no. 4, pp. 194-195, 2000.
- E. Vargas-Díez, E. Daudén, M. Jones-Caballero, and A. García-Díez, “Madelung's disease involving the tongue,” Journal of the American Academy of Dermatology, vol. 42, no. 3, pp. 511–513, 2000.
- F. Bassetto, C. Scarpa, F. De Stefano, and L. Busetto, “Surgical treatment of multiple symmetric lipomatosis with ultrasound-assisted liposuction,” Annals of Plastic Surgery, vol. 73, no. 5, pp. 559–562, 2014.
- M. A. Shiffman and A. Di Giuseppe, Liposuction, Springer Berlin Heidelberg, Berlin, Heidelberg, 2006.
- M. Tremp, R. Wettstein, L. A. Tchang, D. J. Schaefer, U. M. Rieger, and D. F. Kalbermatten, “Power-assisted liposuction (PAL) of multiple symmetric lipomatosis (MSL) - A longitudinal study,” Surgery for Obesity and Related Diseases, vol. 11, no. 1, pp. 155–160, 2015.
- C. I. C. Pinto, P. J. M. C. Carvalho, and M. M. O. Correia, “Madelung’s Disease: Revision of 59 Surgical Cases,” Aesthetic Plastic Surgery, vol. 41, no. 2, pp. 359–368, 2017.
Copyright © 2018 Chun-Ye Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.