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BioMed Research International
Volume 2018, Article ID 4067597, 12 pages
https://doi.org/10.1155/2018/4067597
Review Article

Natural Compounds for the Management of Parkinson’s Disease and Attention-Deficit/Hyperactivity Disorder

Laboratory of Neurosciences, Hospital Infantil de México Federico Gómez, Mexico

Correspondence should be addressed to Juan Carlos Corona; xm.ude.gfmih@anorocj

Received 28 June 2018; Revised 31 October 2018; Accepted 11 November 2018; Published 22 November 2018

Guest Editor: Francesco Facchiano

Copyright © 2018 Juan Carlos Corona. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. Dauer and S. Przedborski, “Parkinson's disease: mechanisms and models,” Neuron, vol. 39, no. 6, pp. 889–909, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. C. W. Olanow, D. R. Wakeman, and J. H. Kordower, “Peripheral alpha-synuclein and Parkinson's disease,” Movement Disorders, vol. 29, no. 8, pp. 963–966, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. J. C. Corona and M. R. Duchen, “PPARgamma and PGC-1alpha as therapeutic targets in Parkinson's,” Neurochemical Research, vol. 40, no. 2, pp. 308–316, 2015. View at Publisher · View at Google Scholar
  4. H. Deng, P. Wang, and J. Jankovic, “The genetics of Parkinson disease,” Ageing Research Reviews, vol. 42, pp. 72–85, 2018. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Brichta, P. Greengard, and M. Flajolet, “Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems,” Trends in Neurosciences, vol. 36, no. 9, pp. 543–554, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. B. K. Young, R. Camicioli, and L. Ganzini, “Neuropsychiatric adverse effects of antiparkinsonian drugs. Characteristics, evaluation and treatment,” Drugs & Aging, vol. 10, no. 5, pp. 367–383, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Homayoun, “Parkinson Disease,” Annals of Internal Medicine, vol. 169, no. 5, pp. ITC33–ITC48, 2018. View at Publisher · View at Google Scholar
  8. R. D. White, G. D. Harris, and M. E. Gibson, “Attention Deficit Hyperactivity Disorder and Athletes,” Sports Health, vol. 6, no. 2, pp. 149–156, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Ramassamy, F. Clostre, Y. Christen, and J. Costentin, “Prevention by a Ginkgo biloba Extract (GBE 761) of the Dopaminergic Neurotoxicity of MPTP,” Journal of Pharmacy and Pharmacology, vol. 42, no. 11, pp. 785–789, 1990. View at Publisher · View at Google Scholar · View at Scopus
  10. W.-R. Wu and X.-Z. Zhu, “Involvement of monoamine oxidase inhibition in neuroprotective and neurorestorative effects of Ginkgo biloba extract against MPTP-induced nigrostriatal dopaminergic toxicity in C57 mice,” Life Sciences, vol. 65, no. 2, pp. 157–164, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Cao, S. Sun, and E. T. Tong, “Experimental study on inhibition of neuronal toxical effect of levodopa by ginkgo biloba extract on Parkinson disease in rats,” Journal of Huazhong University of Science and Technology - Medical Sciences, vol. 23, no. 2, pp. 151–153, 2003. View at Google Scholar
  12. M.-S. Kim, J.-I. Lee, W.-Y. Lee, and S.-E. Kim, “Neuroprotective effect of Ginkgo biloba L. extract in a rat model of parkinson's disease,” Phytotherapy Research, vol. 18, no. 8, pp. 663–666, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Kang, J. Chen, Z. Xu, H. Li, and B. Wang, “Protective effects of Ginkgo biloba extract on paraquat-induced apoptosis of PC12 cells,” Toxicology in Vitro, vol. 21, no. 6, pp. 1003–1009, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Rojas, N. Serrano-García, J. J. Mares-Sámano, O. N. Medina-Campos, J. Pedraza-Chaverri, and S. O. Ögren, “EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-induced Parkinsonism in mice: Role of oxidative stress,” European Journal of Neuroscience, vol. 28, no. 1, pp. 41–50, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. M. A. El-Ghazaly, N. A. Sadik, E. R. Rashed, and A. A. Abd-El-Fattah, “Neuroprotective effect of EGb761(R) and low-dose whole-body gamma-irradiation in a rat model of Parkinson's disease,” Toxicology & Industrial Health, vol. 31, no. 12, pp. 1128–1143, 2015. View at Publisher · View at Google Scholar
  16. Y. Q. Wang, M. Y. Wang, X. R. Fu et al., “Neuroprotective effects of ginkgetin against neuroinjury in Parkinson's disease model induced by MPTP via chelating iron,” Free Radical Research, vol. 49, no. 9, pp. 1069–1080, 2015. View at Publisher · View at Google Scholar
  17. J. Hua, N. Yin, B. Yang et al., “Ginkgolide B and bilobalide ameliorate neural cell apoptosis in α-synuclein aggregates,” Biomedicine & Pharmacotherapy, vol. 96, pp. 792–797, 2017. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Kuang, L. Yang, Z. Rao et al., “Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson's Disease,” Canadian Journal of Neurological Sciences, vol. 45, no. 2, pp. 182–187, 2018. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Rudakewich, F. Ba, and C. G. Benishin, “Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1),” Planta Medica, vol. 67, no. 6, pp. 533–537, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. X.-C. Chen, Y. Chen, Y.-G. Zhu, F. Fang, and L.-M. Chen, “Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons,” Acta Pharmacologica Sinica, vol. 23, no. 9, pp. 829–834, 2002. View at Google Scholar · View at Scopus
  21. J. Van Kampen, H. Robertson, T. Hagg, and R. Drobitch, “Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease,” Experimental Neurology, vol. 184, no. 1, pp. 521–529, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. X.-C. Chen, Y.-C. Zhou, F. Fang, Y. Chen, Y.-G. Zhu, and L.-M. Chen, “Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress,” Acta Pharmacologica Sinica, vol. 26, no. 1, pp. 56–62, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Hu, R. Han, S. Mak, and Y. Han, “Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells,” Journal of Ethnopharmacology, vol. 135, no. 1, pp. 34–42, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. W. Jiang, Z. Wang, Y. Jiang, M. Lu, and X. Li, “Ginsenoside Rg1 ameliorates motor function in an animal model of Parkinson's disease,” Pharmacology, vol. 96, no. 1-2, pp. 25–31, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. M. T. Ardah, K. E. Paleologou, G. Lv et al., “Ginsenoside Rb1 inhibits fibrillation and toxicity of alpha-synuclein and disaggregates preformed fibrils,” Neurobiology of Disease, vol. 74, pp. 89–101, 2015. View at Publisher · View at Google Scholar · View at Scopus
  26. T.-T. Zhou, G. Zu, X. Wang et al., “Immunomodulatory and neuroprotective effects of ginsenoside Rg1 in the MPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) -induced mouse model of Parkinson's disease,” International Immunopharmacology, vol. 29, no. 2, pp. 334–343, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. T. Zhou, G. Zu, X. Zhang et al., “Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease,” Neuropharmacology, vol. 101, no. 5, pp. 480–489, 2016. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Heng, Q.-S. Zhang, Z. Mu, J.-F. Hu, Y.-H. Yuan, and N.-H. Chen, “Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra,” Toxicology Letters, vol. 243, pp. 7–21, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. E. González-Burgos, C. Fernández-Moriano, R. Lozano, I. Iglesias, and M. P. Gómez-Serranillos, “Ginsenosides Rd and Re co-treatments improve rotenone-induced oxidative stress and mitochondrial impairment in SH-SY5Y neuroblastoma cells,” Food and Chemical Toxicology, vol. 109, pp. 38–47, 2017. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Liu, R.-Y. Zhang, J. Zhao et al., “Ginsenoside Rd protects SH-SY5Y cells against 1-methyl-4-phenylpyridinium induced injury,” International Journal of Molecular Sciences, vol. 16, no. 7, pp. 14395–14408, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. H.-I. Im, W. S. Joo, E. Nam, E.-S. Lee, Y.-J. Hwang, and Y. S. Kim, “Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice,” Journal of Pharmacological Sciences, vol. 98, no. 2, pp. 185–189, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Cheng, G. He, X. Mu et al., “Neuroprotective effect of baicalein against MPTP neurotoxicity: Behavioral, biochemical and immunohistochemical profile,” Neuroscience Letters, vol. 441, no. 1, pp. 16–20, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. X. Mu, G. He, Y. Cheng, X. Li, B. Xu, and G. Du, “Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro,” Pharmacology Biochemistry & Behavior, vol. 92, no. 4, pp. 642–648, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Jiang, Y. Porat-Shliom, Z. Pei et al., “Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism,” Journal of Neurochemistry, vol. 114, no. 2, pp. 419–429, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. J.-H. Lu, M. T. Ardah, S. S. K. Durairajan et al., “Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation,” ChemBioChem, vol. 12, no. 4, pp. 615–624, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. Y.-H. Wang, H.-T. Yu, X.-P. Pu, and G.-H. Du, “Baicalein prevents 6-hydroxydopamine-induced mitochondrial dysfunction in SH-SY5Y cells via inhibition of mitochondrial oxidation and up-regulation of DJ-1 protein expression,” Molecules, vol. 18, no. 12, pp. 14726–14738, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. E. Lee, H. R. Park, S. T. Ji, Y. Lee, and J. Lee, “Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model by downregulating the activations of nuclear factor-κB, ERK, and JNK,” Journal of Neuroscience Research, vol. 92, no. 1, pp. 130–139, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. X. Xue, H. Liu, L. Qi et al., “Baicalein ameliorated the upregulation of striatal glutamatergic transmission in the mice model of Parkinson's disease,” Brain Research Bulletin, vol. 103, pp. 54–59, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. Q. Hu, V. N. Uversky, M. Huang et al., “Baicalein inhibits alpha-synuclein oligomer formation and prevents progression of alpha-synuclein accumulation in a rotenone mouse model of Parkinson's disease,” Biochim Biophys Acta, vol. 1862, no. 10, pp. 1883–1890, 2016. View at Google Scholar
  40. K.-C. Hung, H.-J. Huang, Y.-T. Wang, and A. M.-Y. Lin, “Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo,” Journal of Ethnopharmacology, vol. 194, pp. 522–529, 2016. View at Publisher · View at Google Scholar · View at Scopus
  41. H.-Q. Chen, Z.-Y. Jin, X.-J. Wang, X.-M. Xu, L. Deng, and J.-W. Zhao, “Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation,” Neuroscience Letters, vol. 448, no. 2, pp. 175–179, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. L. Hu, J. Yen, Y. Shen, K. Wu, M. Wu, and Y. Ho, “Luteolin Modulates 6-Hydroxydopamine-Induced Transcriptional Changes of Stress Response Pathways in PC12 Cells,” PLoS ONE, vol. 9, no. 5, p. e97880, 2014. View at Publisher · View at Google Scholar
  43. S. P. Patil, P. D. Jain, J. S. Sancheti, P. J. Ghumatkar, R. Tambe, and S. Sathaye, “Neuroprotective and neurotrophic effects of Apigenin and Luteolin in MPTP induced parkinsonism in mice,” Neuropharmacology, vol. 86, pp. 192–202, 2014. View at Publisher · View at Google Scholar · View at Scopus
  44. N. Haleagrahara, C. J. Siew, N. K. Mitra, and M. Kumari, “Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum,” Neuroscience Letters, vol. 500, no. 2, pp. 139–143, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Lv, T. Hong, Z. Yang et al., “Effect of quercetin in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced mouse model of parkinson's disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 928643, 6 pages, 2012. View at Publisher · View at Google Scholar
  46. S. S. Karuppagounder, S. K. Madathil, M. Pandey, R. Haobam, U. Rajamma, and K. P. Mohanakumar, “Quercetin up-regulates mitochondrial complex-I activity to protect against programmed cell death in rotenone model of Parkinson's disease in rats,” Neuroscience, vol. 236, pp. 136–148, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. M. Ay, J. Luo, M. Langley et al., “Molecular mechanisms underlying protective effects of quercetin against mitochondrial dysfunction and progressive dopaminergic neurodegeneration in cell culture and MitoPark transgenic mouse models of Parkinson's Disease,” Journal of Neurochemistry, vol. 141, no. 5, pp. 766–782, 2017. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Li and X.-P. Pu, “Neuroprotective effect of kaempferol against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease,” Biological & Pharmaceutical Bulletin, vol. 34, no. 8, pp. 1291–1296, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. G. Filomeni, I. Graziani, D. de Zio et al., “Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease,” Neurobiology of Aging, vol. 33, no. 4, pp. 767–785, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. M. M. Khan, S. S. Raza, H. Javed et al., “Rutin protects dopaminergic neurons from oxidative stress in an animal model of Parkinson's disease,” Neurotoxicity Research, vol. 22, no. 1, pp. 1–15, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. K. B. Magalingam, A. Radhakrishnan, and N. Haleagrahara, “Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity,” International Journal of Molecular Medicine, vol. 32, no. 1, pp. 235–240, 2013. View at Publisher · View at Google Scholar · View at Scopus
  52. K. B. Magalingam, A. Radhakrishnan, and N. Haleagrahara, “Protective effects of flavonol isoquercitrin, against 6-hydroxydopamine (6-OHDA)-induced toxicity in PC12 cells,” BMC Research Notes, vol. 7, p. 49, 2014. View at Publisher · View at Google Scholar · View at Scopus
  53. C. Anusha, T. Sumathi, and L. D. Joseph, “Protective role of apigenin on rotenone induced rat model of Parkinson's disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis,” Chemico-Biological Interactions, vol. 269, pp. 67–79, 2017. View at Publisher · View at Google Scholar · View at Scopus
  54. T. Baluchnejadmojarad, N. Jamali-Raeufy, S. Zabihnejad, N. Rabiee, and M. Roghani, “Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson's disease: Possible involvement of PI3K/ERβ signaling,” European Journal of Pharmacology, vol. 801, pp. 72–78, 2017. View at Publisher · View at Google Scholar · View at Scopus
  55. M. R. Poetini, S. M. Araujo, M. Trindade de Paula et al., “Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson's disease,” Chemico-Biological Interactions, vol. 279, pp. 177–186, 2018. View at Publisher · View at Google Scholar · View at Scopus
  56. M. S. Antunes, A. T. R. Goes, S. P. Boeira, M. Prigol, and C. R. Jesse, “Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice,” Nutrition Journal , vol. 30, no. 11-12, pp. 1415–1422, 2014. View at Publisher · View at Google Scholar
  57. J. H. Sudati, F. A. Vieira, and S. S. Pavin, “Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster,” NeuroToxicology, vol. 37, pp. 118–126, 2013. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Sridharan, K. Mohankumar, S. P. Jeepipalli et al., “Neuroprotective effect of Valeriana wallichii rhizome extract against the neurotoxin MPTP in C57BL/6 mice,” NeuroToxicology, vol. 51, pp. 172–183, 2015. View at Publisher · View at Google Scholar
  59. S. Ingale and S. Kasture, “Protective effect of standardized extract of Passiflora incarnata flower in parkinson's and alzheimer's disease,” Ancient Science of Life, vol. 36, no. 4, pp. 200–206, 2017. View at Publisher · View at Google Scholar
  60. L. E. M. Brandão and D. Nôga, “Passiflora cincinnata extract delays the development of motor signs and prevents dopaminergic loss in a mice model of parkinson’s disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, Article ID 8429290, 11 pages, 2017. View at Publisher · View at Google Scholar
  61. M. A. Gómez del Rio, M. I. Sánchez-Reus, I. Iglesias et al., “Neuroprotective properties of standardized extracts of hypericum perforatum on rotenone model of parkinson's disease,” CNS and Neurological Disorders - Drug Targets, vol. 12, no. 5, pp. 665–679, 2013. View at Publisher · View at Google Scholar · View at Scopus
  62. Z. Kiasalari, T. Baluchnejadmojarad, and M. Roghani, “Hypericum perforatum hydroalcoholic extract mitigates motor dysfunction and is neuroprotective in intrastriatal 6-hydroxydopamine rat model of parkinson’s disease,” Cellular and Molecular Neurobiology, vol. 36, no. 4, pp. 521–530, 2016. View at Publisher · View at Google Scholar · View at Scopus
  63. M. R. Lyon, J. C. Cline, J. T. De Zepetnek, J. J. Shan, P. Pang, and C. Benishin, “Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study,” Journal of Psychiatry & Neuroscience, vol. 26, no. 3, pp. 221–228, 2001. View at Google Scholar · View at Scopus
  64. B. Salehi, R. Imani, M. R. Mohammadi et al., “Ginkgo biloba for attention-deficit/hyperactivity disorder in children and adolescents: a double blind, randomized controlled trial,” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 34, no. 1, pp. 76–80, 2010. View at Publisher · View at Google Scholar · View at Scopus
  65. H. Uebel-von Sandersleben, A. Rothenberger, B. Albrecht, L. G. Rothenberger, S. Klement, and N. Bock, “Ginkgo biloba extract EGb 761 in children with ADHD,” Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie, vol. 42, no. 5, pp. 337–347, 2014. View at Publisher · View at Google Scholar
  66. F. Shakibaei, M. Radmanesh, E. Salari, and B. Mahaki, “Ginkgo biloba in the treatment of attention-deficit/hyperactivity disorder in children and adolescents. A randomized, placebo-controlled, trial,” Complementary Therapies in Clinical Practice, vol. 21, no. 2, pp. 61–67, 2015. View at Publisher · View at Google Scholar · View at Scopus
  67. H. Niederhofer, “Panax ginseng may improve some symptoms of attention-deficit hyperactivity disorder,” Journal of Dietary Supplements, vol. 6, no. 1, pp. 22–27, 2009. View at Publisher · View at Google Scholar · View at Scopus
  68. S. H. Lee, W. S. Park, and M. H. Lim, “Clinical effects of korean red ginseng on attention deficit hyperactivity disorder in children: an observational study,” Journal of Ginseng Research, vol. 35, no. 2, pp. 226–234, 2011. View at Publisher · View at Google Scholar · View at Scopus
  69. H.-J. Ko, I. Kim, J.-B. Kim et al., “Effects of Korean red ginseng extract on behavior in children with symptoms of inattention and hyperactivity/impulsivity: a double-blind randomized placebo-controlled trial,” Journal of Child and Adolescent Psychopharmacology, vol. 24, no. 9, pp. 501–508, 2014. View at Publisher · View at Google Scholar · View at Scopus
  70. Y. Nam, E.-J. Shin, S. W. Shin et al., “YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET,” Food and Chemical Toxicology, vol. 65, pp. 280–292, 2014. View at Publisher · View at Google Scholar · View at Scopus
  71. J. Trebatická, S. Kopasová, Z. Hradečná et al., “Treatment of ADHD with French maritime pine bark extract, Pycnogenol,” European Child and Adolescent Psychiatry, vol. 15, no. 6, pp. 329–335, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. Z. Chovanová, J. Muchová, M. Sivoňová et al., “Effect of polyphenolic extract, Pycnogenol, on the level of 8-oxoguanine in children suffering from attention deficit/hyperactivity disorder,” Free Radical Research, vol. 40, no. 9, pp. 1003–1010, 2006. View at Publisher · View at Google Scholar · View at Scopus
  73. M. Dvořáková, M. Sivoňová, J. Trebatická et al., “The effect of polyphenolic extract from pine bark, Pycnogenol, on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD),” Redox Report, vol. 11, no. 4, pp. 163–172, 2006. View at Publisher · View at Google Scholar · View at Scopus
  74. S. Y. Yoon, I. D. Peña, S. M. Kim et al., “Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro,” Archives of Pharmacal Research, vol. 36, no. 1, pp. 134–140, 2013. View at Publisher · View at Google Scholar · View at Scopus
  75. I. C. Dela Peña, S. Y. Yoon, Y. Kim et al., “5,7-Dihydroxy-6-methoxy-4-phenoxyflavone, a derivative of oroxylin A improves attention-deficit/hyperactivity disorder (ADHD)-like behaviors in spontaneously hypertensive rats,” European Journal of Pharmacology, vol. 715, no. 1–3, pp. 337–344, 2013. View at Publisher · View at Google Scholar · View at Scopus
  76. R. Zhou, X. Han, J. Wang, and J. Sun, “Effect of baicalin on behavioral characteristics of rats with attention deficit hyperactivity disorder,” Zhongguo Dang Dai Er Ke Za Zhi, vol. 19, no. 8, pp. 930–937, 2017. View at Publisher · View at Google Scholar
  77. R. Razlog, J. Pellow, and S. J. White, “A pilot study on the efficacy of Valeriana officinalis mother tincture and Valeriana officinalis 3X in the treatment of attention deficit hyperactivity disorder,” Health SA Gesondheid, vol. 17, no. 1, pp. 1–7, 2012. View at Publisher · View at Google Scholar · View at Scopus
  78. S. Akhondzadeh, M. R. Mohammadi, and F. Momeni, “Passiflora incarnata in the treatment of attention-deficit hyperactivity disorder in children and adolescents,” Therapy, vol. 2, no. 4, pp. 609–614, 2005. View at Publisher · View at Google Scholar · View at Scopus
  79. W. Weber, A. Vander Stoep, R. L. McCarty, N. S. Weiss, J. Biederman, and J. McClellan, “Hypericum perforatum (St John's Wort) for attention-deficit/hyperactivity disorder in children and adolescents: a randomized controlled trial,” The Journal of the American Medical Association, vol. 299, no. 22, pp. 2633–2641, 2008. View at Publisher · View at Google Scholar · View at Scopus
  80. H. Niederhofer, “St. John's wort may improve some symptoms of attention-deficit hyperactivity disorder,” Natural Product Research, vol. 24, no. 3, pp. 203–205, 2010. View at Publisher · View at Google Scholar · View at Scopus
  81. F. V. DeFeudis and K. Drieu, “Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications,” Current Drug Targets, vol. 1, no. 1, pp. 25–58, 2000. View at Publisher · View at Google Scholar · View at Scopus
  82. P. Rojas, P. Montes, C. Rojas, N. Serrano-García, and J. C. Rojas-Castañeda, “Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: Therapeutic perspectives,” Nutrition Journal , vol. 28, no. 11-12, pp. 1081–1088, 2012. View at Publisher · View at Google Scholar · View at Scopus
  83. C. Rendeiro, J. S. Rhodes, and J. P. E. Spencer, “The mechanisms of action of flavonoids in the brain: Direct versus indirect effects,” Neurochemistry International, vol. 89, pp. 126–139, 2015. View at Publisher · View at Google Scholar · View at Scopus
  84. H. D. Kim, K. H. Jeong, U. J. Jung, and S. R. Kim, “Naringin treatment induces neuroprotective effects in a mouse model of Parkinson's disease in vivo, but not enough to restore the lesioned dopaminergic system,” The Journal of Nutritional Biochemistry, vol. 28, pp. 140–146, 2016. View at Publisher · View at Google Scholar · View at Scopus
  85. D. M. de Oliveria, G. Barreto, D. V. G. de Andrade et al., “Cytoprotective effect of valeriana officinalis extract on an in vitro experimental model of parkinson disease,” Neurochemical Research, vol. 34, no. 2, pp. 215–220, 2009. View at Publisher · View at Google Scholar · View at Scopus
  86. K. Dhawan, S. Dhawan, and A. Sharma, “Passiflora: a review update,” Journal of Ethnopharmacology, vol. 94, no. 1, pp. 1–23, 2004. View at Publisher · View at Google Scholar · View at Scopus
  87. J. Barnes, L. A. Anderson, and J. D. Phillipson, “St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties,” Journal of Pharmacy and Pharmacology, vol. 53, no. 5, pp. 583–600, 2001. View at Publisher · View at Google Scholar · View at Scopus
  88. G. Polanczyk, M. S. de Lima, B. L. Horta, J. Biederman, and L. A. Rohde, “The worldwide prevalence of ADHD: a systematic review and metaregression analysis,” The American Journal of Psychiatry, vol. 164, no. 6, pp. 942–948, 2007. View at Publisher · View at Google Scholar · View at Scopus
  89. E. G. Willcutt, “The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review,” Neurotherapeutics, vol. 9, no. 3, pp. 490–499, 2012. View at Publisher · View at Google Scholar · View at Scopus
  90. S. V. Faraone, P. Asherson, T. Banaschewski et al., “Attention-deficit/hyperactivity disorder,” Nature Reviews Disease Primers, vol. 1, p. 15020, 2015. View at Publisher · View at Google Scholar
  91. J. Prince, “Catecholamine dysfunction in attention-deficit/hyperactivity disorder: an update,” Journal of Clinical Psychopharmacology, vol. 28, no. 3, suppl 2, pp. S39–S45, 2008. View at Publisher · View at Google Scholar · View at Scopus
  92. A. L. Lopresti, “Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies,” ADHD Attention Deficit and Hyperactivity Disorders, vol. 7, no. 4, pp. 237–247, 2015. View at Publisher · View at Google Scholar · View at Scopus
  93. L. Briars and T. Todd, “A review of pharmacological management of attention-deficit/hyperactivity disorder,” The Journal of Pediatric Pharmacology and Therapeutics, vol. 21, no. 3, pp. 192–206, 2016. View at Publisher · View at Google Scholar
  94. J. Biederman, T. Spencer, and T. Wilens, “Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder,” The International Journal of Neuropsychopharmacology, vol. 7, no. 1, pp. 77–97, 2004. View at Publisher · View at Google Scholar · View at Scopus
  95. V. A. Reed, J. K. Buitelaar, E. Anand et al., “The safety of atomoxetine for the treatment of children and adolescents with attention-deficit/hyperactivity disorder: a comprehensive review of over a decade of research,” CNS Drugs, vol. 30, no. 7, pp. 603–628, 2016. View at Publisher · View at Google Scholar · View at Scopus
  96. J. Lee, N. Grizenko, V. Bhat, S. Sengupta, A. Polotskaia, and R. Joober, “Relation between therapeutic response and side effects induced by methylphenidate as observed by parents and teachers of children with ADHD,” BMC Psychiatry, vol. 11, p. 70, 2011. View at Publisher · View at Google Scholar · View at Scopus
  97. T. E. Wilens, A. Kwon, S. Tanguay et al., “Characteristics of adults with attention deficit hyperactivity disorder plus substance use disorder: The role of psychiatric comorbidity,” American Journal on Addictions, vol. 14, no. 4, pp. 319–327, 2005. View at Publisher · View at Google Scholar · View at Scopus
  98. H. R. Searight, K. Robertson, T. Smith, S. Perkins, and B. K. Searight, “Complementary and Alternative Therapies for Pediatric Attention Deficit Hyperactivity Disorder: A Descriptive Review,” ISRN Psychiatry, vol. 2012, Article ID 804127, 8 pages, 2012. View at Publisher · View at Google Scholar
  99. P. L. Le Bars, M. M. Katz, N. Berman, T. M. Itil, A. M. Freedman, and A. F. Schatzberg, “A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group,” The Journal of the American Medical Association, vol. 278, no. 16, pp. 1327–1332, 1997. View at Publisher · View at Google Scholar · View at Scopus
  100. A. J. Schmidt, J.-C. Krieg, U. M. Hemmeter et al., “Impact of plant extracts tested in attention-deficit/hyperactivity disorder treatment on cell survival and energy metabolism in human neuroblastoma SH-SY5Y cells,” Phytotherapy Research, vol. 24, no. 10, pp. 1549–1553, 2010. View at Publisher · View at Google Scholar · View at Scopus
  101. R.-Y. Zhou, J.-J. Wang, Y. You et al., “Effect of baicalin on ATPase and LDH and its regulatory effect on the AC/cAMP/PKA signaling pathway in rats with attention deficit hyperactivity disorder,” Zhongguo Dang Dai Er Ke Za Zhi, vol. 19, no. 5, pp. 576–582, 2017. View at Google Scholar · View at Scopus
  102. A. A. J. Verlaet, B. Ceulemans, H. Verhelst et al., “Effect of Pycnogenol(R) on attention-deficit hyperactivity disorder (ADHD): study protocol for a randomised controlled trial,” Trials, vol. 18, no. 1, p. 145, 2017. View at Google Scholar · View at Scopus
  103. D. Benke, A. Barberis, S. Kopp et al., “GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts,” Neuropharmacology, vol. 56, no. 1, pp. 174–181, 2009. View at Publisher · View at Google Scholar · View at Scopus
  104. K. Appel, T. Rose, B. Fiebich, T. Kammler, C. Hoffmann, and G. Weiss, “Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L.,” Phytotherapy Research, vol. 25, no. 6, pp. 838–843, 2011. View at Publisher · View at Google Scholar · View at Scopus
  105. M. Miroddi, G. Calapai, M. Navarra, P. L. Minciullo, and S. Gangemi, “Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials,” Journal of Ethnopharmacology, vol. 150, no. 3, pp. 791–804, 2013. View at Publisher · View at Google Scholar · View at Scopus
  106. V. Butterweck, “Mechanism of action of St John's wort in depression: what is known?” CNS Drugs, vol. 17, no. 8, pp. 539–562, 2003. View at Publisher · View at Google Scholar · View at Scopus