Simvastatin Improves the Jaw Bone Microstructural Defect Induced by High Cholesterol Diet in Rats by Regulating Autophagic Flux

<div><b>Effects of simvastatin on the autophagic regulation in HC rats.</b> The levels of LC3 (a) and p62 (b) expression were assessed by qPCR. LC3 positive cells were observed in NC (c), HC (d), and HC + SIM (e), and p62 positive cells were observed in NC (f), HC (g), and HC + SIM (h) by IHC. Results are expressed as mean ± SD of each group. 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BioMed Research International

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Figure 4

Figure 4: Simvastatin Improves the Jaw Bone Microstructural Defect Induced by High Cholesterol Diet in Rats by Regulating Autophagic Flux 