Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-κB Activation in Human Myeloid Leukemia THP-1 Cells
Inhibition of Hsp90 reduces TLR5 cell surface expression. Cell surface expression of TLR5 in THP-1 cells was examined by flow cytometry analysis. THP-1 cells were treated with or without the Hsp90 inhibitors, (a) GA, (b) 17-AAG, and (c) radicicol at various concentrations for 24 h. Relative fluorescence intensity was measured, and data are expressed as means of relative expression ratio ± SD (). versus DMSO- or MeOH-treated group.
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