Comparison of Elution Characteristics and Compressive Strength of Biantibiotic-Loaded PMMA Bone Cement for Spacers: Copal® Spacem with Gentamicin and Vancomycin versus Palacos® R+G with Vancomycin

Table 2

Comparison of determined antibiotic concentrations after 28 days sorted by specimen group and measured antibiotic.

Specimen group by amount of added vancomycin in g	Measured antibiotic	Antibiotic concentration for COP; mean in μg/ml (CI 95%)	Antibiotic concentration for PAL; mean in μg/ml (CI95%)	p
2	Gentamicin	2.46 (2.03 – 2.91)	5.21 (2.62 – 7.80)	0.041
4	Gentamicin	2.97 (2.35 – 3.59)	4.93 (3.84 – 6.03)	0.002
6	Gentamicin	2.53 (2.02 – 3.03)	4.08 (2.43 – 5.73)	0.043
2	Vancomycin	5.52 (5.01 – 6.02)	5.52 (3.45 – 7.59)	1.000
4	Vancomycin	12.03 (11.19 – 12.88)	12.82 (6.80 – 18.84)	0.754
6	Vancomycin	17.73 (15.92 – 19.55)	11.45 (8.41 – 14.49)	0.001