Research Article

Long Noncoding RNA LOC441178 Reduces the Invasion and Migration of Squamous Carcinoma Cells by Targeting ROCK1

Figure 1

LncRNA array analysis revealed downregulation of LOC441178 in OSCCs. (a) Volcano plots were drawn to show the differentially expressed lncRNAs between OSCCs and control group in GSE9844. Four times fold changes, and a p value of 0.05 was used as division standard. (b) Volcano plots of GSE30784. LOC441178 is one of the most significant lncRNAs with a greater than 14-fold downregulation. (c) The LOC441178 expression levels in OSCC samples were significantly lower than control group in GSE9844. p < 0.05. (d) The LOC441178 expression levels in GSE30784. (e) The Kaplan-Meier survival curve showed that OSCC patients with low LOC441178 level (red line, n=33) owned a shorter postoperation survival time compared to the high expression subgroup.
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