Lats1/2-Mediated Alteration of Hippo Signaling Pathway Regulates the Fate of Bone Marrow-Derived Mesenchymal Stem Cells

Figure 5

The effects of high and low expression of Lats1 and Lats2 on the proliferation of BMSCs. The growth curves of the BMSCs were evaluated by the CCK-8 assay after transduction for 7 days. The proliferation rate of the MSC-Lats1 and MSC-Lats2 group was significantly lower than the MSC-GFP group from days 2 to 7 (a). The proliferation rates of the MSC-shLats1 and MSC-shLats2 group were significantly higher than the MSC-shcontrol group from days 3 to 7 and from days 4 to 7, respectively (b). The results are representatives of three independent experiments (n = 3; P < 0.05 vs. MSC-GFP, P < 0.05 vs. MSC-shcontrol).

(a)

(b)