The Impact of Pathologic Upgrading of Gleason Score 7 Prostate Cancer on the Risk of the Biochemical Recurrence after Radical Prostatectomy

Table 3

Multivariate analysis of biochemical recurrence-free survival based on the four-group categorization of pathologic Gleason score 7 prostate cancer.

Variables	Biochemical recurrence-free survival
	HR (95% CI)	p value
Age	1.01 (0.99–1.03)	0.349
PSA range
<10	Reference
10–20	1.19 (0.911–1.54)	0.206
20	1.50 (1.11–2.03)	0.008
Pathologic findings
ECE (+)	1.25 (0.98–1.59)	0.074
SVI (+)	1.33 (0.98–1.82)	0.070
Surgical margin (+)	1.89 (1.49–2.39)	<0.001
Four-group categorization
Upgraded GS 3+4	0.50 (0.35–0.70)	<0.001
Nonupgraded GS 3+4	Reference	<0.001
Upgraded GS 4+3	1.20 (0.86–1.68)	0.274
Nonupgraded GS 4+3	1.55 (1.19–2.02)	0.001

CI: confidence interval, ECE: extracapsular extension; GS: Gleason score; HR: hazard ratio; PSA: prostate-specific antigen; SVI: seminal vesicle invasion.