Remote Ischemic Postconditioning Protects against Myocardial Ischemia-Reperfusion Injury by Inhibition of the RAGE-HMGB1 Pathway

Figure 1

Experimental protocols. Mice were randomly assigned into five groups: (a) sham group (mice underwent sham surgery); (b) I/R group (mice underwent 40 min left anterior descending artery occlusion, followed by 120 min reperfusion); (c) RIPostC group (mice were underwent ischemic reperfusion injury, where remote conditioning was applied at the beginning of cardiac reperfusion). (d) RIPostC + Ly group (mice were injected with the PI3K inhibitor LY294002 and then underwent ischemic reperfusion injury, where remote conditioning was applied at the beginning of cardiac reperfusion). I/R: ischemia/reperfusion; RIPostC: remote ischemic postconditioning.