Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction

Figure 2

LIG reduced APP and the A1-42 level in the brains of APP/PS1 transgenic mice. (a-b) Representative images and quantitative graphs of thioflavin-S staining in the brain of APP/PS1 mice were showed (n ≥ 10 images per group). (c) The levels of oligomer and monomer, APP, ADAM10, and SAPPα detected in the hippocampus. (d) The levels of oligomer and monomer, APP, ADAM10, and SAPPα detected in the cortex. Data are presented as the mean ± SEM (n = 6 per group). WT: 9-month-old wild-type C57 male mice; APP/PS1: 9-month-old APP/PS1 male mice; LIG10: 9-month-old APP/PS1 mice + LIG (10 mg/kg); LIG40: 9-month-old APP/PS1 mice + LIG (40 mg/kg). p < 0.05; p < 0.01 versus 9-month-old wild-type C57 male mice; p < 0.05; p < 0.01 versus 9-month-old APP/PS1 mice.

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