Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction

Figure 4

LIG ameliorated mitochondrial morphology in the brains of APP/PS1 transgenic mice. We used COX-IV as a loading control for mitochondrial proteins. (a) Mitochondrial morphology from the hippocampal CA1 area of each group. (b) Mitochondria number from the hippocampal CA1 area of each group. (c) Mitochondrial lengths from the hippocampal CA1 area of each group. Data are presented as the mean ± SEM (n ≥ 10 images per group). (d) The levels of DRP1, OPA1, MFN1, and MFN2 were detected in the hippocampus. (e) The levels of DRP1, OPA1, MFN1, and MFN2 were detected in the cortex. Data are presented as the mean ± SEM (n = 6 per group). WT: 9-month-old wild-type C57 male mice; APP/PS1: 9-month-old APP/PS1 male mice; LIG10: 9-month-old APP/PS1 mice + LIG (10 mg/kg); LIG40: 9-month-old APP/PS1 mice + LIG (40 mg/kg). p < 0.05; p < 0.01 versus 9-month-old wild-type C57 male mice; p < 0.05; p < 0.01 versus 9-month-old APP/PS1 mice.

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