Clinical and Experimental Evidences of Hydrogen Sulfide Involvement in Lead-Induced Hypertension

Table 1

KCl-induced contraction, PHE-induced contraction, and ACh-induced relaxation in thoracic aorta of Saline, NaHS, Pb, and Pb + NaHS rat.

	Aortic rings
	+E				−E
	Saline	NaHS	Pb	Pb + NaHS	Saline	NaHS	Pb	Pb + NaHS
KCl , g	0.87 ± 0.06	0.84 ± 0.06	0.79 ± 0.05	0.75 ± 0.10	0.75 ± 0.11	0.83 ± 0.06	0.64 ± 0.04	0.78 ± 0.08
PHE , g	1.05 ± 0.02	1.36 ± 0.05	0.80 ± 0.0	0.84 ± 0.0	1.51 ± 0.0	1.79 ± 0.0	1.20 ± 0.0	1.56 ± 0.0
PHE pEC50,	6.84 ± 0.06	7.00 ± 0.10	6.75 ± 0.08	6.85 ± 0.12	7.50 ± 0.1	7.54 ± 0.1	6.95 ± 0.11	7.35 ± 0.1
ACh , %	97.79 ± 1.47	93.76 ± 2.01	93.78 ± 2.10	93.88 ± 2.12	—	—	—	—
ACh pEC50,	7.07 ± 0.20	6.99 ± 0.20	7.13 ± 0.22	7.54 ± 0.25	—	—	—	—
ACh + L-NAME , %	20.38 ± 3.34	9.60 ± 0.70	23.08 ± 3.80	38.90 ± 4.8	—	—	—	—

Data represents mean ± SEM (). versus Saline. versus NaHS. versus Pb. versus intact vessels (+E) of the same animal group.