Doxazosin and Carvedilol Treatment Improves Hepatic Regeneration in a Hamster Model of Cirrhosis
Effect of the reduction of fibrosis and recovery of the hepatic function through the administration of the α/β adrenoblockers, doxazosin and carvedilol. Compared to the animals with cirrhosis and without treatment, those treated with either of the test drugs showed a clear reduction in the percentage of hepatic fibrosis (a), a decrease in the enzymes related to cellular damage (e.g., ALT and AST), and an increase in the biosynthetic capacity of albumin and total proteins (b-e). It was evaluated with analysis of variance test with the Tukey post hoc values which are expressed as the mean ± SD. ,, and for the treated groups versus the intact and cirrhosis groups (n=5).
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