Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population
Table 3
The single SNP association studies result of NLRP1 on the risk of PV.
Genotype
Cases ()
Controls ()
value
Adjusted value
Statistical model
OR (95% CI)
rs8079034
TT
16 (3.0%)
24 (3.9%)
Additive
0.8171
0.8374
TC
164 (30.3%)
186 (30.4%)
Dominant
0.5288
0.6392
1.066
CC
360 (66.7%)
402 (65.7%)
Recessive
0.8040
0.8601
()
T/C
196/884
234/990
0.6732
0.7022
Heterozygous
0.9955
0.9998
18.1%/81.9%
19.1%/80.9%
rs11651270
TT
302 (55.9%)
360 (58.8%)
Additive
0.3893
0.3873
TC
214 (39.6%)
214 (35.0%)
Dominant
0.4828
0.5006
1.032
CC
24 (4.4%)
38 (6.2%)
Recessive
0.3464
0.3666
()
T/C
818/262
934/290
0.8204
0.8320
Heterozygous
0.2480
0.2711
75.7%/24.3%
76.3%/23.7%
rs11657747
GG
526 (97.4%)
596 (97.4%)
Additive
--
0.9999
GA
14 (2.6%)
16 (2.6%)
Dominant
0.9869
0.9998
0.992
AA
0 (0)
0 (0)
Recessive
--
0.9999
()
G/A
1066/14
1208/16
0.9869
0.9998
Heterozygous
0.9870
0.9999
98.7%/1.3%
98.7%/1.3%
rs878329
GG
364 (67.4%)
400 (65.3%)
Additive
0.8724
0.8946
GC
164 (30.4%)
198(32.4%)
Dominant
0.60365
0.6660
0.931
CC
12 (2.2%)
14 (2.3%)
Recessive
0.9580
0.9999
()
G/C
892/188
998/226
0.62939
0.6359
Heterozygous
0.6089
0.6540
82.6%/17.4%
81.5%/18.5%
, number; , model-based statistical value; , value adjusted by permutation; OR, odds ratio (we used the major allele as the reference allele to calculate the OR); 95% CI, 95% confidence interval.
