Research Article

Alkaline Phosphatase Kinetics Predict Metastasis among Prostate Cancer Patients Who Experience Relapse following Radical Prostatectomy

Table 3

Comparison of patients with versus without alkaline phosphatase (AP) data needed for calculating AP velocity (APV).

Alkaline Phosphatase Data Availablep-value
No  
(n=1,082)
Yes  
(n=701)

Age at CaP1 Diagnosis (years), Mean ± SD262.1 ± 762.6 ± 6.40.16
Age at RP3(years), Mean ± SD62.3 ± 762.8 ± 6.40.17
Time from RP3 to Distant Metastasis (years), Mean ± SD7.3 ± 5.410.1 ± 4.7<.0001
Distant Metastasis, N ()142 (13.1)63 (9)
Neo- and/or Adjuvant Treatments Received, N ()195 (18)127 (18.1)0.96
Salvage Treatments Received, N ()544 (50.3)437 (62.3)<.0001
PSA Doubling Time (Months), N ()0.36
 Missing69 (6.4)22 (3.1)
 <10211 (19.5)129 (18.4)
 ≥ 10802 (74.1)550 (78.5)
D’Amico risk stratum, N ()0.70
 Missing298 (27.5)165 (23.5)
 Low241 (22.3)171 (24.4)
 Intermediate283 (26.2)199 (28.4)
 High260 (24)166 (23.7)
Race, N ()0.35
 Missing20 (1.8)8 (1.1)
 African American224 (20.7)163 (23.3)
 Caucasian790 (73)494 (70.5)
 Others48 (4.5)36 (5.1)
PSA at CaP Diagnosis, N ()0.27
 Missing222 (20.5)126 (18)
 <10582 (53.8)371 (52.9)
 10-20177 (16.4)139 (19.8)
 >20101 (9.3)65 (9.3)
Pathologic Gleason Sum, N ()0.17
 Missing227 (21)98 (14)
 ≤6328 (30.3)234 (33.3)
 3+4249 (23)201 (28.7)
 4+3112 (10.4)73 (10.4)
 ≥ 8166 (15.3)95 (13.6)
Pathological T stage, N ()0.011
 Missing54 (5)15 (2.1)
 pT2436 (40.3)334 (47.6)
 pT3-T4592 (54.7)352 (50.3)
Positive Surgical Margin Status, N ()506 (46.8)311 (44.4)0.16
Positive Extracapsular Extension, N ()511 (47.2)265 (37.8)<.0001
Positive Seminal Vesicle Invasion, N ()163 (15.1)96 (13.7)0.27

CaP = prostate cancer.
SD= standard deviation.
RP = radical prostatectomy.