Research Article
Alkaline Phosphatase Kinetics Predict Metastasis among Prostate Cancer Patients Who Experience Relapse following Radical Prostatectomy
Table 3
Comparison of patients with versus without alkaline phosphatase (AP) data needed for calculating AP velocity (APV).
| | Alkaline Phosphatase Data Available | p-value | No (n=1,082) | Yes (n=701) |
| Age at CaP1 Diagnosis (years), Mean ± SD2 | 62.1 ± 7 | 62.6 ± 6.4 | 0.16 | Age at RP3(years), Mean ± SD | 62.3 ± 7 | 62.8 ± 6.4 | 0.17 | Time from RP3 to Distant Metastasis (years), Mean ± SD | 7.3 ± 5.4 | 10.1 ± 4.7 | <.0001 | Distant Metastasis, N () | 142 (13.1) | 63 (9) | | Neo- and/or Adjuvant Treatments Received, N () | 195 (18) | 127 (18.1) | 0.96 | Salvage Treatments Received, N () | 544 (50.3) | 437 (62.3) | <.0001 | PSA Doubling Time (Months), N () | | | 0.36 | Missing | 69 (6.4) | 22 (3.1) | | <10 | 211 (19.5) | 129 (18.4) | | ≥ 10 | 802 (74.1) | 550 (78.5) | | D’Amico risk stratum, N () | | | 0.70 | Missing | 298 (27.5) | 165 (23.5) | | Low | 241 (22.3) | 171 (24.4) | | Intermediate | 283 (26.2) | 199 (28.4) | | High | 260 (24) | 166 (23.7) | | Race, N () | | | 0.35 | Missing | 20 (1.8) | 8 (1.1) | | African American | 224 (20.7) | 163 (23.3) | | Caucasian | 790 (73) | 494 (70.5) | | Others | 48 (4.5) | 36 (5.1) | | PSA at CaP Diagnosis, N () | | | 0.27 | Missing | 222 (20.5) | 126 (18) | | <10 | 582 (53.8) | 371 (52.9) | | 10-20 | 177 (16.4) | 139 (19.8) | | >20 | 101 (9.3) | 65 (9.3) | | Pathologic Gleason Sum, N () | | | 0.17 | Missing | 227 (21) | 98 (14) | | ≤6 | 328 (30.3) | 234 (33.3) | | 3+4 | 249 (23) | 201 (28.7) | | 4+3 | 112 (10.4) | 73 (10.4) | | ≥ 8 | 166 (15.3) | 95 (13.6) | | Pathological T stage, N () | | | 0.011 | Missing | 54 (5) | 15 (2.1) | | pT2 | 436 (40.3) | 334 (47.6) | | pT3-T4 | 592 (54.7) | 352 (50.3) | | Positive Surgical Margin Status, N () | 506 (46.8) | 311 (44.4) | 0.16 | Positive Extracapsular Extension, N () | 511 (47.2) | 265 (37.8) | <.0001 | Positive Seminal Vesicle Invasion, N () | 163 (15.1) | 96 (13.7) | 0.27 |
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CaP = prostate cancer. SD= standard deviation. RP = radical prostatectomy. |