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BioMed Research International
Volume 2018 (2018), Article ID 4756313, 6 pages
Clinical Study

Acute Effect of Hypervolemic Hemodilution on Retrobulbar Hemodynamics in Anterior Ischemic Optic Neuropathy

1Department of Ophthalmology, Uniklinik RWTH Aachen, Aachen, Germany
2Augen-Beleg-Klinik, Krankenhaus Barmherzige Brüder, Regensburg, Germany
3Augenzentrum Annapark, Alsdorf, Germany

Correspondence should be addressed to Marion Bienert; ed.nehcaaku@treneibm

Received 16 May 2017; Revised 20 November 2017; Accepted 26 November 2017; Published 6 February 2018

Academic Editor: Atsushi Mizota

Copyright © 2018 Marion Bienert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods. 24 patients with acute NAION were included. Retrobulbar hemodynamics were measured using color Doppler imaging before and 15 min after intravenous infusion of 250 cc 10% hydroxyethyl starch (HES). Peak systolic velocity (PSV), end diastolic velocity (EDV), and Pourcelot’s resistive index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), and short posterior ciliary arteries (PCAs). Results. After infusion of HES blood flow velocities significantly increased in the CRA (PSV from to   (); EDV from to   ()) and in the PCAs (PSV from to   (); EDV from to  cm/sec ()). The RI of all retrobulbar vessels remained unaffected. Blood pressure and heart rate remained unchanged. Conclusions. Hypervolemic hemodilution has an acute effect on blood flow velocities in the CRA and PCAs in NAION patients. Increased blood flow in the arteries supplying the optic nerve head may lead to a better perfusion in NAION patients. This trial is registered with DRKS00012603.