BioMed Research International / 2018 / Article / Fig 2

Review Article

A Brief Review on the Neuroprotective Mechanisms of Vitexin

Figure 2

The major targets are involved in neurodegeneration and CNS injury that can be modulated by vitexin. The aggregation of toxic oligomers generates free radicals and exacerbates oxidative and nitrosative stress, in turn active as eminent and mortal signaling pathways, a self-perpetuating vicious cycle. Vitexin prevents an apoptoxic neuronal attack in acute brain lesions revealed by the increase of Bcl-2, and increases Bax and caspases-3 and attenuates a neurotoxicity induced by the release of calcium in NMDA receptors.

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