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BioMed Research International
Volume 2018, Article ID 4786329, 7 pages
https://doi.org/10.1155/2018/4786329
Research Article

Variability in Ultrasound Backscatter Induced by Trabecular Microstructure Deterioration in Cancellous Bone

1Department of Electronic Engineering, Fudan University, Shanghai 200433, China
2Institute of Acoustics, Tongji University, No. 1239 Siping Road, Shanghai 200092, China
3State Key Laboratory of ASIC and System, Fudan University, Shanghai 200433, China
4Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention (MICCAI) of Shanghai, Shanghai 200032, China
5Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada

Correspondence should be addressed to Chengcheng Liu; nc.ude.ijgnot@uilgnehcgnehc and Dean Ta; nc.ude.naduf@adt

Received 26 October 2017; Accepted 1 January 2018; Published 29 January 2018

Academic Editor: Weibao Qiu

Copyright © 2018 Xingxing Chou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To determine the relationship between the ultrasonic backscatter parameters and trabecular microstructural variations in cancellous bone, three erosion procedures were performed to simulate various changes in the cancellous bone microstructure. The finite difference time domain (FDTD) method was used to simulate the backscatter signal in cancellous bone. Ultrasonic backscatter properties were derived as functions of the porosity when the ultrasound incident directions were perpendicular and parallel to the major trabeculae direction (MTD), respectively. The variability in the apparent backscatter coefficient (ABC) and apparent integrated backscatter (AIB) due to the trabecular microstructure was revealed. Significant negative correlations between the backscatter parameters (ABC and AIB) and the porosity of the cancellous bone were observed. The simulations showed that the ABC and AIB were influenced by the direction of the trabecular microstructural variations. The linear regressions between the ultrasonic backscatter parameters (ABC and AIB) and the porosity showed significantly different slopes for three erosion procedures when they are ultrasonically perpendicular (for ABC, −1.22 dB, −0.98 dB, and −0.46 dB; for AIB, −0.74 dB, −0.69 dB, and −0.25 dB) and parallel (for ABC, −1.87 dB, −0.69 dB, and −0.51 dB; for AIB, −0.9 dB, −0.5 dB, and −0.34 dB) to the MTD. This paper investigated the relationship between ultrasonic backscatter and cancellous bone microstructure deterioration and indicated that the ultrasonic backscatter could be affected by cancellous bone microstructure deterioration direction.