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Figure 2: The effects of miR-219-5p on in vitro proliferation and invasion of HCC cells. (a) The alterations in cell proliferation of HepG2 cells after upregulation of miR-219-5p by mimic transfection (left) and MHCC-97H cells after knockdown of miR-219-5p by antagomir (right) were detected by CCK8 assay. (b) The cell cycle distribution of HepG2 and MHCC-97H cells after transfection with miR-219-5p mimic or antagomir. (c) Representative pictures of apoptosis of HepG2 and MHCC-97H cells after transfection with miR-219-5p mimic or antagomir detected by flow cytometry. (d) Migration and invasion of cells were determined by transwell assay in HepG2 and MHCC-97H cells treated with miR-219-5p mimic/antagomir and the corresponding negative control (magnification ×100). Data are shown as mean ± SD. , versus the control.