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Figure 3: Effects of miR-219-5p on in vivo tumor growth and lung metastasis of HCC. (a, b) The differences in tumor size and volume of the subcutaneous implantation models of MHCC-97H cells after transfection with miR-219-5p antagomir or antagomir NC. (c) Comparison of the tumor volumes in the orthotopic implantation models of MHCC-97H cells after transfection with antagomir to knockdown miR-219-5p. (d) Representative images of lung metastasis (left) and comparison of the numbers of lung metastatic nodes in orthotopic implantation nude mice models of MHCC-97H cells after transfected with miR-219-5p antagomir or antagomir NC (magnification ×200). Data are shown as mean ± SD. , .