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BioMed Research International
Volume 2018, Article ID 4898153, 8 pages
https://doi.org/10.1155/2018/4898153
Research Article

Increased Micronuclei Frequency in Oral and Lingual Epithelium of Treated Diabetes Mellitus Patients

1Faculty of Odontology, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico
2Faculty of Biological and Chemical Sciences, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico
3Faculty of Biology, Autonomous University of Sinaloa, 80010 Culiacán, SIN, Mexico
4Boston Children’s Hospital and Harvard Medical School, Harvard University, Boston, MA 02115, USA

Correspondence should be addressed to Rosalío Ramos-Payán; xm.ude.sau@proilasor

Received 14 September 2017; Revised 1 November 2017; Accepted 19 November 2017; Published 9 January 2018

Academic Editor: Konstantinos Kantartzis

Copyright © 2018 Jesús Emilo Quintero Ojeda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. G. Andreassi, R. Barale, P. Iozzo, and E. Picano, “The association of micronucleus frequency with obesity, diabetes and cardiovascular disease,” Mutagenesis, vol. 26, no. 1, pp. 77–83, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. B. S. da Silva, D. L. Rovaris, R. M. Bonotto et al., “The influence on DNA damage of glycaemic parameters, oral antidiabetic drugs and polymorphisms of genes involved in the DNA repair system,” Mutagenesis, vol. 28, no. 5, pp. 525–530, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. N. B. Freimer and C. Sabatti, “Human genetics: variants in common diseases,” Nature, vol. 445, no. 7130, pp. 828–830, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Zimmet, K. G. M. M. Alberti, and J. Shaw, “Global and societal implications of the diabetes epidemic,” Nature, vol. 414, no. 6865, pp. 782–787, 2001. View at Publisher · View at Google Scholar · View at Scopus
  5. World Health Organization, “World Health Organization, 2014. The top 10 causes of death,” http://www.who.int/mediacentre/factsheets/fs310/en/.
  6. International Diabetes Federation, The Diabetes Atlas, International Diabetes Federation, Brussels, Belgium, 7th edition, 2015.
  7. M. Hernández-Ávila, J. P. Gutiérrez, and N. Reynoso-Noverón, “Diabetes mellitus en México. El estado de la epidemia,” Salud Pública de México, vol. 55, pp. s129–s136, 2013. View at Publisher · View at Google Scholar
  8. Secretaria de Salud, Principales Causas de Morbilidad Nacional, SUIVE/DGE, Ed., Secretaria de Salud, CDMX, México, 2014.
  9. C. A. Negrato, O. Tarzia, L. Jovanovič, and L. E. M. Chinellato, “Periodontal disease and diabetes mellitus,” Journal of Applied Oral Science, vol. 21, no. 1, pp. 1–12, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. E. M. Kogawa, D. C. Grisi, D. P. Falcão et al., “Impact of glycemic control on oral health status in type 2 diabetes individuals and its association with salivary and plasma levels of chromogranin A,” Archives of Oral Biolog, vol. 62, pp. 10–19, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. C. M. Silva-Boghossian, S. R. Orrico, D. Gonçalves, F. O. Correa, and A. P. Colombo, “Microbiological changes after periodontal therapy in diabetic patients with inadequate metabolic control,” Brazilian Oral Research, vol. 28, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  12. J. Aitken-Saavedra, G. Rojas-Alcayaga, A. Maturana-Ramírez et al., “Salivary gland dysfunction markers in type 2 diabetes mellitus patients,” Journal of Clinical and Experimental Dentistry, vol. 7, no. 4, Article ID 52329, pp. e501–e505, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. A. R. Moreira, I. A. Passos, F. C. Sampaio, M. S. M. Soares, and R. J. Oliveira, “Flow rate, pH and calcium concentration of saliva of children and adolescents with type 1 diabetes mellitus,” Brazilian Journal of Medical and Biological Research, vol. 42, no. 8, pp. 707–711, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. V. L. Carneiro, F. C. Fraiz, F. M. Ferreira, T. P. Pintarelli, A. C. Oliveira, and M. C. Boguszewski, “The influence of glycemic control on the oral health of children and adolescents with diabetes mellitus type 1,” Archives of Endocrinology and Metabolism, vol. 59, no. 6, pp. 535–540, 2015. View at Google Scholar
  15. A. P. Robertson, “Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes,” The Journal of Biological Chemistry, vol. 279, no. 41, pp. 42351–42354, 2004. View at Publisher · View at Google Scholar · View at Scopus
  16. D. N. Binici, A. Karaman, M. Coşkun, A. U. Oğlu, and F. Uçar, “Genomic damage in patients with type-2 diabetes mellitus,” Genetic Counseling, vol. 24, no. 2, pp. 149–156, 2013. View at Google Scholar
  17. P. E. Tolbert, C. M. Shy, and J. W. Allen, “Micronuclei and other nuclear anomalies in buccal smears: a field test in snuff users,” American Journal of Epidemiology, vol. 134, no. 8, pp. 840–850, 1991. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Thomas, N. Holland, C. Bolognesi et al., “Buccal micronucleus cytome assay,” Nature Protocols, vol. 4, no. 6, pp. 825–837, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Bonassi, E. Coskun, M. Ceppi, C. Lando, C. Bolognesi, and S. Burgaz, “The HUman MicroNucleus project on eXfoLiated buccal cells (HUMN(XL)): the role of life-style, host factors, occupational exposures, health status, and assay protocol,” Mutation Research, vol. 728, no. 3, pp. 88–97, 2011. View at Google Scholar
  20. H. Donmez-Altuntas, F. Sahin, F. Bayram et al., “Evaluation of chromosomal damage, cytostasis, cytotoxicity, oxidative DNA damage and their association with body-mass index in obese subjects,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 771, pp. 30–36, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. S. C. T. Corbi, A. S. Bastos, S. R. P. Orrico et al., “Elevated micronucleus frequency in patients with type 2 diabetes, dyslipidemia and periodontitis,” Mutagenesis, vol. 29, no. 6, pp. 433–439, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Flores-Garcia, O. Torres-Bugarin, J. S. Velarde-Félix, H. Rangel-Villalobos, E. A. Zepeda-Carrillo, and A. Rodríguez-Trejo, “Micronuclei and other nuclear anomalies in exfoliated buccal mucosa cells of Mexican women with breast cancer,” Journal of the Balkan Union of Oncology, vol. 19, no. 4, pp. 895–899, 2014. View at Google Scholar
  23. M. Witczak, T. Ferenc, E. Gulczyńska, D. Nowakowska, D. Łopaczyńska, and J. Wilczyński, “Elevated frequencies of micronuclei in pregnant women with type 1 diabetes mellitus and in their newborns,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 763, pp. 12–17, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Prasad, S. C. Bronson, T. Warrier et al., “Evaluation of DNA damage in Type 2 diabetes mellitus patients with and without peripheral neuropathy: a study in South Indian population,” Journal of Natural Science, Biology and Medicine, vol. 6, no. 1, pp. 80–84, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Salimi, B. Broumand, and H. Mozdarani, “Association of elevated frequency of micronuclei in peripheral blood lymphocytes of type 2 diabetes patients with nephropathy complications,” Mutagenesis, vol. 31, no. 6, pp. 627–633, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Gopal, N. Malathi, and B. T. Reddy, “Efficacy of oral exfoliative cytology in diabetes mellitus patients: a light microscopic and confocal microscopic study,” The Journal of Contemporary Dental Practice, vol. 16, no. 3, pp. 215–221, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Müllner, H. Brath, A. Nersesyan et al., “Nuclear anomalies in exfoliated buccal cells in healthy and diabetic individuals and the impact of a dietary intervention,” Mutagenesis, vol. 29, no. 1, pp. 1–6, 2014. View at Publisher · View at Google Scholar · View at Scopus
  28. G. M. Zúñiga González and B. C. Gómez Meda, “La prueba de micronúcleos,” in Revista de divulgacion cientifica y tecnologica de la universidad veracruzana, 19, 2006. View at Google Scholar
  29. CDC and B.M.I., “Body Mass Index (BMI),” 2016, https://www.cdc.gov/healthyweight/assessing/bmi/. View at Publisher · View at Google Scholar
  30. A. Grindel, B. Guggenberger, L. Eichberger et al., “Oxidative stress, DNA damage and DNA repair in female patients with diabetes mellitus type 2,” PLoS ONE, vol. 11, no. 9, Article ID e0162082, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. D. J. Xavier, P. Takahashi, F. S. Manoel-Caetano et al., “One-week intervention period led to improvements in glycemic control and reduction in DNA damage levels in patients with type 2 diabetes mellitus,” Diabetes Research and Clinical Practice, vol. 105, no. 3, pp. 356–363, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Merecz, L. Markiewicz, A. Sliwinska et al., “Analysis of oxidative DNA damage and its repair in Polish patients with diabetes mellitus type 2: role in pathogenesis of diabetic neuropathy,” Advances in Medical Sciences, vol. 60, no. 2, pp. 220–230, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. V. Calabrese, C. Cornelius, V. Leso et al., “Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes,” Biochimica et Biophysica Acta, vol. 1822, no. 5, pp. 729–736, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. O. Aouacheri, S. Saka, M. Krim, A. Messaadia, and I. Maidi, “The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus,” Canadian Journal of Diabetes, vol. 39, no. 1, pp. 44–49, 2015. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Gupta, J. K. Gambhir, O. Kalra et al., “Association of biomarkers of inflammation and oxidative stress with the risk of chronic kidney disease in type 2 diabetes mellitus in North Indian population,” Journal of Diabetes and its Complications, vol. 27, no. 6, pp. 548–552, 2013. View at Publisher · View at Google Scholar · View at Scopus
  36. C. Bolognesi, S. Knasmueller, A. Nersesyan et al., “Inter-laboratory consistency and variability in the buccal micronucleus cytome assay depends on biomarker scored and laboratory experience: results from the HUMNxl international inter-laboratory scoring exercise,” Mutagenesis, vol. 32, no. 2, pp. 257–266, 2017. View at Publisher · View at Google Scholar
  37. C. Bolognesi, S. Bonassi, S. Knasmueller et al., “Clinical application of micronucleus test in exfoliated buccal cells: a systematic review and metanalysis,” Mutation Research—Reviews in Mutation Research, vol. 766, pp. 20–31, 2015. View at Publisher · View at Google Scholar · View at Scopus
  38. C. S. Pereira, P. Molz, R. P. Palazzo et al., “DNA damage and cytotoxicity in adult subjects with prediabetes,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 753, no. 2, pp. 76–81, 2013. View at Publisher · View at Google Scholar
  39. C. M. Ripsin, H. Kang, and R. J. Urban, “Management of blood glucose in type 2 diabetes mellitus,” American Family Physician, vol. 79, no. 1, pp. 29–36, 2009. View at Google Scholar · View at Scopus
  40. M. K. Harishankar, S. Logeshwaran, S. Sujeevan, K. N. Aruljothi, M. A. Dannie, and A. Devi, “Genotoxicity evaluation of metformin and glimepiride by micronucleus assay in exfoliated urothelial cells of type 2 diabetes mellitus patients,” Food and Chemical Toxicology, vol. 83, pp. 146–150, 2015. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Cheki, A. Shirazi, A. Mahmoudzadeh, J. T. Bazzaz, and S. J. Hosseinimehr, “The radioprotective effect of metformin against cytotoxicity and genotoxicity induced by ionizing radiation in cultured human blood lymphocytes,” Mutation Research—Genetic Toxicology and Environmental Mutagenesis, vol. 809, pp. 24–32, 2016. View at Publisher · View at Google Scholar · View at Scopus
  42. J. R. Sant'Anna, J. P. Yajima, L. J. Rosada, C. C. Franco, A. J. Prioli, V. A. Della-Rosa et al., “Metformin's performance in in vitro and in vivo genetic toxicology studies,” Experimental Biology and Medicine (Maywood), vol. 238, no. 7, pp. 803–810, 2013. View at Google Scholar
  43. J. R. De Sant'Anna, C. C. Da Silva Franco, P. C. De Freitas Mathias, and M. A. A. De Castro-Prado, “Assessment of in vivo and in vitro genotoxicity of glibenclamide in eukaryotic cells,” PLoS ONE, vol. 10, no. 3, Article ID e0120675, 2015. View at Publisher · View at Google Scholar · View at Scopus
  44. L. M. Berstein, J. O. Kvatchevskaya, T. E. Poroshina et al., “Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer,” Journal of Cancer Research and Clinical Oncology, vol. 130, no. 11, pp. 687–693, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. R. K. Menon, R. M. Cohen, M. A. Sperling, W. S. Cutfield, F. Mimouni, and J. C. Khoury, “Transplacental passage of insulin in pregnant women with insulin-dependent diabetes mellitus: its role in fetal macrosomia,” The New England Journal of Medicine, vol. 323, no. 5, pp. 309–315, 1990. View at Publisher · View at Google Scholar · View at Scopus
  46. E. M. Othman, A. Leyh, and H. Stopper, “Insulin mediated DNA damage in mammalian colon cells and human lymphocytes in vitro,” Mutation Research—Fundamental and Molecular Mechanisms of Mutagenesis, vol. 745-746, pp. 34–39, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. E. M. Othman, R. G. Oli, P.-A. Arias-Loza, M. C. Kreissl, and H. Stopper, “Metformin protects kidney cells from insulin-mediated genotoxicity in vitro and in male Zucker diabetic fatty rats,” Endocrinology, vol. 157, no. 2, pp. 548–559, 2016. View at Publisher · View at Google Scholar · View at Scopus
  48. L. M. Martinez-Perez, R. M. Cerda-Flores, E. C. Gallegos-Cabriales, M. I. Dávila-Rodríguez, E. Ibarra-Costilla, and E. I. Cortés-Gutiérrez, “Frequency of micronuclei in Mexicans with type 2 diabetes mellitus,” Prague Medical Report, vol. 108, no. 3, pp. 248–255, 2007. View at Google Scholar
  49. P. S. Kulkarni, L. M. Ambani, and S. D. Bhandarkar, “Chromosomal studies in diabetic patients treated with chlorpropamide,” Food and Chemical Toxicology, vol. 23, no. 6, pp. 625–628, 1985. View at Publisher · View at Google Scholar · View at Scopus